Molecular Diagnostics Services

• Recognizing customer needs

• Offering customer-tailored solutions

• Long lasting DNA methylation expertise

• Broad range of methods implemented

• Specific bioinformatics workflows available

Infinium Methylation EPIC  v2 Kit 

 DNA-hydroxymethylation (EPIC v2 extension)   

Infinium Mouse Methylation BeadChip   

TWIST Methyl Capture Library Seq: (single C resolution; enzymatic deamination) 

480plex MSRE*qPCR cancer panel: (no single C resolution)

Customized MSRE*qPCR panels: (no single C resolution)

MSP**-Assays:  (no single C resolution) 

• We owned and protected High Performance Computing (HPC) hardware for computationally expensive tasks
  • No security / data protection issues with third party cloud computing providers.
  • Scalable through integration of additional HPC hardware from other centers within the institute (institute wide HPC cluster planned)
• Reproducible and fully transparent code development and pipeline execution
  • Code sharing through private code repository (gitlab) upon request.
• Professional project management
• Highly trained and experienced staff with proven scientific track record

(Multi-) OMICS data analysis

• Consulting for study design
  • Sample size calculation
  • Definition of experimental layout
  • Statistical analysis plan
• Pipelines available for most omics data types and research questions
  • NGS – read mapping, QC, preprocessing, also for WGBS and RRBS
  • Variant and / or DMR calling
  • EPIC data analysis
  • RRBS analysis
  • RNAseq
  • ChIPseq / ATACseq (developed on demand)
  • Immunomics: HD Peptide arrays
• (Multi-) OMICS Interpretation
  • Gene Set Enrichment
  • Interaction networks
  • De-novo network generation
  • Also available as academic collaboration