PLCG1 (phospho Y783) monoclonal antibody, clone C4 (PE)

Flow Cytometry

Flow cytometric analysis of Hela cells unstained imatinib treated (blue) or stained treated with imatinib (red) or with pervanadate (green) using PLCG1 (phospho Y783) monoclonal antibody (PE).

Entrez GeneID

5335

Gene Name

PLCG1

Gene Alias

PLC-II, PLC1, PLC148, PLCgamma1

Gene Description

phospholipase C, gamma 1

Omim ID

172420

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

1-phosphatidyl-D-myo-inositol-4,5-bisphosphate|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1|OTTHUMP00000031787|OTTHUMP00000178982|PLC-gamma-1|inositoltrisphosphohydrolase|monophosphatidylinositol phosphodiesterase|phosphatidylinositol