Moxifloxacin (Hydrochloride) [186826-86-8]
Cat# HY-66011-50mg
Size : 50mg
Brand : MedChemExpress
Moxifloxacin Hydrochloride (BAY 12-8039) is an oral 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia.
For research use only. We do not sell to patients.
Moxifloxacin Hydrochloride Chemical Structure
CAS No. : 186826-86-8
This product is a controlled substance and not for sale in your territory.
Based on 7 publication(s) in Google Scholar
Other Forms of Moxifloxacin Hydrochloride:
- Moxifloxacin In-stock
- (Rac)-Moxifloxacin In-stock
- Moxifloxacin-d4 Get quote
- Moxifloxacin-d3 hydrochloride Get quote
- Moxifloxacin-d3-1 hydrochloride Get quote
- Moxifloxacin-13C,d3 hydrochloride Get quote
- rac cis-Moxifloxacin-d4 hydrochloride Get quote
- Moxifloxacin hydrochloride monohydrate Get quote
View All Antibiotic Isoform Specific Products:
Description |
Moxifloxacin Hydrochloride (BAY 12-8039) is an oral 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia[1][2]. |
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IC50 & Target |
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In Vitro |
The in vitro activities of Moxifloxacin Hydrochloride (BAY 12-8039) and Amoxicillin are compared by time-kill curve and inhibition of intracellular growth experiments by using a model of bone marrow-derived mouse macrophages infected by L. monocytogenes EGDe. Moxifloxacin acts much more rapidly, beginning to exert its effects in the first 3 h and achieving complete broth sterilization within 24 h of incubation. Moxifloxacin appears to have a protective effect against macrophage lysis, as many cells are still viable after 24 h of incubation[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Moxifloxacin (BAY 12-8039; 12 mg/kg; intravenous injection; once-three times per day; for 7 days; white male Wistar rats) treatment every 8 hours is accompanied by longer survival. Tissue cultures 30 hours after bacterial challenge shows considerably less bacterial overgrowth in the spleens and lungs of moxifloxacin-treated than in salinetreated animals and without being toxic[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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Molecular Weight |
437.89 |
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Formula |
C21H25ClFN3O4 |
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CAS No. |
186826-86-8 |
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Appearance |
Solid |
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Color |
Light yellow to green yellow |
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SMILES |
O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N(C4)C[C@]5(04)[C@@]4(04)CCCN5)=C3OC)C1=O)O.Cl |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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Solvent & Solubility |
In Vitro:
DMSO : 25 mg/mL (57.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : 16.67 mg/mL (38.07 mM; Need ultrasonic) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Purity & Documentation |
Purity: 99.75% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O / DMSO | 1 mM | 2.2837 mL | 11.4184 mL | 22.8368 mL | 57.0920 mL |
5 mM | 0.4567 mL | 2.2837 mL | 4.5674 mL | 11.4184 mL | |
10 mM | 0.2284 mL | 1.1418 mL | 2.2837 mL | 5.7092 mL | |
15 mM | 0.1522 mL | 0.7612 mL | 1.5225 mL | 3.8061 mL | |
20 mM | 0.1142 mL | 0.5709 mL | 1.1418 mL | 2.8546 mL | |
25 mM | 0.0913 mL | 0.4567 mL | 0.9135 mL | 2.2837 mL | |
30 mM | 0.0761 mL | 0.3806 mL | 0.7612 mL | 1.9031 mL | |
DMSO | 40 mM | 0.0571 mL | 0.2855 mL | 0.5709 mL | 1.4273 mL |
50 mM | 0.0457 mL | 0.2284 mL | 0.4567 mL | 1.1418 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Moxifloxacin Hydrochloride Related Classifications
- Anti-infection
- Bacterial Antibiotic