Ionomycin [56092-81-0]
Cat# HY-13434-1mg
Size : 1mg(14.1mM*100uLinEthanol)
Brand : MedChemExpress
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC).
For research use only. We do not sell to patients.
Ionomycin Chemical Structure
CAS No. : 56092-81-0
This product is a controlled substance and not for sale in your territory.
Other In-stock Forms of Ionomycin:
-
Ionomycin purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2022 Dec 8;303:116031. [Abstract]
- Calcium imaging in HEK293T cells expressing E649A, E652K, and E652D mutants responds to 10 nM capsaicin, the cocktail of 10 nM capsaicin and 30 μM s-RhTx, 10 μM capsaicin, and 10 μM ionomycin, respectively.
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Description |
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC)[1][2][3]. |
IC50 & Target |
Calcium ionophore[1] |
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In Vitro |
Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
Clinical Trial |
|
Molecular Weight |
709.01 |
Formula |
C41H72O9 |
CAS No. |
56092-81-0 |
Appearance |
Liquid |
Color |
Colorless to light yellow |
SMILES |
O=C(O)CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C(O)/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@@H]2O[C@](C)([C@H](O)C)CC2)(C)O1)=O |
Structure Classification |
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Initial Source |
Streptomyces conglobatus |
Shipping | Room temperature in continental US; may vary elsewhere. |
Storage |
Solution, -20°C, 2 years |
Solvent & Solubility |
In Vitro:
Ethanol : 100 mg/mL (141.04 mM; Need ultrasonic) DMSO : 100 mg/mL (141.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: ≥99.0% |
References |
|
Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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Ethanol / DMSO | 1 mM | 1.4104 mL | 7.0521 mL | 14.1042 mL | 35.2604 mL |
5 mM | 0.2821 mL | 1.4104 mL | 2.8208 mL | 7.0521 mL | |
10 mM | 0.1410 mL | 0.7052 mL | 1.4104 mL | 3.5260 mL | |
15 mM | 0.0940 mL | 0.4701 mL | 0.9403 mL | 2.3507 mL | |
20 mM | 0.0705 mL | 0.3526 mL | 0.7052 mL | 1.7630 mL | |
25 mM | 0.0564 mL | 0.2821 mL | 0.5642 mL | 1.4104 mL | |
30 mM | 0.0470 mL | 0.2351 mL | 0.4701 mL | 1.1753 mL | |
40 mM | 0.0353 mL | 0.1763 mL | 0.3526 mL | 0.8815 mL | |
50 mM | 0.0282 mL | 0.1410 mL | 0.2821 mL | 0.7052 mL | |
60 mM | 0.0235 mL | 0.1175 mL | 0.2351 mL | 0.5877 mL | |
80 mM | 0.0176 mL | 0.0882 mL | 0.1763 mL | 0.4408 mL | |
100 mM | 0.0141 mL | 0.0705 mL | 0.1410 mL | 0.3526 mL |
Ionomycin Related Classifications
- Infection Cancer
- Cancer Targeted Therapy Cancer Immunotherapy Cancer Metabolism and Metastasis
- Membrane Transporter/Ion Channel Neuronal Signaling TGF-beta/Smad Epigenetics Anti-infection Apoptosis
- Calcium Channel PKC Bacterial Apoptosis Antibiotic