This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.
Synonyms
VIM, RP11-124N14.1, CTRCT30
Clonality
Polyclonal
Immunogen
Vimentin purified from Calf lens
Specificity
Specific detection of vimentin (Mr 57,000 polypeptide). Tumors specifically detected: Sarcoma (including myosarcoma), lymphoma, melanoma.
Reactivity
Bovine, Human, Mouse
Applications
IHC, WB
Form
Stabilized Serum
Storage
2-8C
References
Magin TM et al. (1990) Eur J Cell Biol 53: 333-348Boehnke K et al. (2007) Eur J Cell Biol 86: 731-746
Background
This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.
Supplier
ARP
View product citations for antibody 03-GP53 on CiteAb
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