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> Corn oil [8001-30-7]

Corn oil [8001-30-7]

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Cat# HY-Y1888-50mL

Size : 50mL

Brand : MedChemExpress

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Corn oil, extracted from the germ of corn, can be used as a carrier for agent molecules.

For research use only. We do not sell to patients.

Corn oil Chemical Structure

Corn oil Chemical Structure

CAS No. : 8001-30-7

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Based on 70 publication(s) in Google Scholar

Description

Corn oil, extracted from the germ of corn, can be used as a carrier for agent molecules.

In Vivo

Corn oil-gavaged rats have 54% lower serum growth hormone (GH) levels, and replacement of GH into corn oil-gavaged rats by osmotic minipump infusion increase in situ MNCL cell proliferation to rates observed in water-gavaged animals[1].
Corn oil is commonly used as a feed additive or a delivery vehicle for lipophilic substances In an animal research setting[3].
Corn oil can become contaminated, and cause death/systemic infections several days after IP injections, so corn oil should be aliquoted and frozen (recommendation); thaw and make fresh solution each time.
Corn oil is more recommended for gavage administration[4].
Intraperitoneal oil application causes local inflammation with depletion of resident peritoneal macrophages[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6J mice (n = 90; age, 6 to 7 wk)[3]
Dosage: 0.1 mL.
Administration: Intraperitoneal injection every 48 h for a total of 4 injections over a 7-d period.
Result: At day 21, pharmaceutical-grade (PG) corn oil had a significantly higher pathology score compared with nonpharmaceutical-grade corn oil. No other significant differences between the corn oil groups were observed. The use of nonpharmaceutical grade corn oil did not result in adverse clinical consequences and is presumed safe to use for intraperitoneal injection in mice.
CAS No.

8001-30-7

Appearance

Liquid (Density: 0.90 g/cm3)

Color

Colorless to light yellow

SMILES

[Corn oil]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 10 mg/mL (Need ultrasonic)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

SDS (393 KB)

COA (243 KB)

Handling Instructions (2659 KB)
References

  • [1]. Hursting SD, et al. Inhibition of rat mononuclear cell leukemia by corn oil gavage: in vivo, in situ and immune competence studies. Carcinogenesis. 1994 Feb;15(2):193-9.  [Content Brief]

    [2]. Gilbertson JR, et al. Inhibition of growth of Morris hepatomas 7777 and 7800 by corn oil. Oncology. 1977;34(2):62-4.  [Content Brief]

    [3]. Jennifer S Hubbard, et al. Effects of Repeated Intraperitoneal Injection of Pharmaceutical-grade and Nonpharmaceutical-grade Corn Oil in Female C57BL/6J Mice. J Am Assoc Lab Anim Sci. 2017 Nov 1;56(6):779-785.  [Content Brief]

    [4]. Administration Of Drugs and Experimental Compounds in Mice and Rats

    [5]. Elisenda Alsina-Sanchis, et al. Intraperitoneal Oil Application Causes Local Inflammation with Depletion of Resident Peritoneal Macrophages. Mol Cancer Res. 2021 Feb;19(2):288-300.  [Content Brief]

  • [1]. Hursting SD, et al. Inhibition of rat mononuclear cell leukemia by corn oil gavage: in vivo, in situ and immune competence studies. Carcinogenesis. 1994 Feb;15(2):193-9.

    [2]. Gilbertson JR, et al. Inhibition of growth of Morris hepatomas 7777 and 7800 by corn oil. Oncology. 1977;34(2):62-4.

    [3]. Jennifer S Hubbard, et al. Effects of Repeated Intraperitoneal Injection of Pharmaceutical-grade and Nonpharmaceutical-grade Corn Oil in Female C57BL/6J Mice. J Am Assoc Lab Anim Sci. 2017 Nov 1;56(6):779-785.

    [4]. Administration Of Drugs and Experimental Compounds in Mice and Rats

    [5]. Elisenda Alsina-Sanchis, et al. Intraperitoneal Oil Application Causes Local Inflammation with Depletion of Resident Peritoneal Macrophages. Mol Cancer Res. 2021 Feb;19(2):288-300.

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Corn oil Related Classifications

  • Others
  • Others
  • Biochemical Assay Reagents
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  • Keywords:

    Corn oil8001-30-7Biochemical Assay ReagentsInhibitorinhibitorinhibit

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