Catechin [154-23-4]
Cat# HY-N0898-10mg
Size : 10mg
Brand : MedChemExpress
Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
For research use only. We do not sell to patients.
Catechin Chemical Structure
CAS No. : 154-23-4
This product is a controlled substance and not for sale in your territory.
Based on 12 publication(s) in Google Scholar
Other Forms of Catechin:
- (±)-Catechin In-stock
- (+)-Catechin hydrate In-stock
- (-)-Catechin In-stock
- Catechin-13C3 Get quote
View All COX Isoform Specific Products:
Description |
Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. |
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IC50 & Target[1] |
|
||||||||||||
In Vitro |
Catechin ((+)-Catechin) exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||
In Vivo |
Animals treated with Catechin ((+)-Catechin) at the lowest tested dose, i.e., 50 mg/kg, p.o. have spent comparatively more time in exploring the novel object in the choice trial, however, the difference is not statistically significant. Catechin prevents the time-induced episodic memory deficits in a dose-dependent manner, the most effective being 200 mg/kg, p.o.. Treatment with Catechin prevents the rise in MPO level compare to DOX alone treatment group (21.98±9.44 and 36.76±4.39% in the hippocampus and the frontal cortex respectively)[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||
Clinical Trial |
|
||||||||||||
Molecular Weight |
290.27 |
||||||||||||
Formula |
C15H14O6 |
||||||||||||
CAS No. |
154-23-4 |
||||||||||||
Appearance |
Solid |
||||||||||||
Color |
Off-white to yellow |
||||||||||||
SMILES |
O[C@@H]1[C@@H](C2=CC(O)=C(O)C=C2)OC3=CC(O)=CC(O)=C3C1 |
||||||||||||
Structure Classification |
|
||||||||||||
Initial Source |
|
||||||||||||
Shipping | Room temperature in continental US; may vary elsewhere. |
||||||||||||
Storage |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
||||||||||||
Solvent & Solubility |
In Vitro:
DMSO : 100 mg/mL (344.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : 12.5 mg/mL (43.06 mM; Need ultrasonic) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
|
||||||||||||
Purity & Documentation |
Purity: 99.57% |
||||||||||||
References |
|
Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
---|
H2O / DMSO | 1 mM | 3.4451 mL | 17.2253 mL | 34.4507 mL | 86.1267 mL |
5 mM | 0.6890 mL | 3.4451 mL | 6.8901 mL | 17.2253 mL | |
10 mM | 0.3445 mL | 1.7225 mL | 3.4451 mL | 8.6127 mL | |
15 mM | 0.2297 mL | 1.1484 mL | 2.2967 mL | 5.7418 mL | |
20 mM | 0.1723 mL | 0.8613 mL | 1.7225 mL | 4.3063 mL | |
25 mM | 0.1378 mL | 0.6890 mL | 1.3780 mL | 3.4451 mL | |
30 mM | 0.1148 mL | 0.5742 mL | 1.1484 mL | 2.8709 mL | |
40 mM | 0.0861 mL | 0.4306 mL | 0.8613 mL | 2.1532 mL | |
DMSO | 50 mM | 0.0689 mL | 0.3445 mL | 0.6890 mL | 1.7225 mL |
60 mM | 0.0574 mL | 0.2871 mL | 0.5742 mL | 1.4354 mL | |
80 mM | 0.0431 mL | 0.2153 mL | 0.4306 mL | 1.0766 mL | |
100 mM | 0.0345 mL | 0.1723 mL | 0.3445 mL | 0.8613 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Catechin Related Classifications
- Cancer
- Cancer Targeted Therapy Cancer Immunotherapy Cancer Metabolism and Metastasis
- Immunology/Inflammation Apoptosis Anti-infection Metabolic Enzyme/Protease
- COX Apoptosis Influenza Virus Endogenous Metabolite