Anti-IGHM antibody (Clone: MHM-88) {PE}

Clonality:	Monoclonal
Clone ID:	MHM-88
Conjugation:	PE
Isotype:	IgG1k
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:

IGHMUniprot ID=IGHM_HUMAN"

Function	Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts.
Protein Name	Immunoglobulin Heavy Constant Mu Ig Mu Chain C Region Ig Mu Chain C Region Bot Ig Mu Chain C Region Gal Ig Mu Chain C Region Ou
Cellular Localisation	Isoform 1: Secreted During Differentiation B-Lymphocytes Switch From Expression Of Membrane-Bound Igm To Secretion Of Igm Isoform 2: Cell Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-Immunoglobulin Heavy Constant Mu antibody Anti-Ig Mu Chain C Region antibody Anti-Ig Mu Chain C Region Bot antibody Anti-Ig Mu Chain C Region Gal antibody Anti-Ig Mu Chain C Region Ou antibody Anti-IGHM antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance