Anti-Flavocytochrome b558 (Human) mAb-FITC

Cat# D162-4

Size : 50ug


D162-4
Antibody
100 uL

DATA SHEET

Monoclonal antibody conjugated to FITC of 100 µL targeting Flavocytochrome b558 for FCM.

TargetFlavocytochrome b558
Product TypeAntibody
ApplicationFCM
ClonalityMonoclonal
ConjugateFITC
IsotypeIgG1
ImmunogenRich fraction of human cytochrome b<sub>558</sub>
Host SpeciesMouse
Species ReactivityHuman
Formulation50 µg IgG in 100 µL volume of PBS containing 1% BSA and 0.1% ProClin 150.
Research AreaCell Biology
Description/BackgroundThe NADPH oxidase is a multicomponent enzyme that transfers electrons from NADPH to O2 to generate superoxide (O2-), a key part of the phagocytic or neutrophilic respiratory burst response. Flavocytochrome b558 is the catalytic component of the phagocyte NADPH oxidase. It is a transmembrane heterodimer composed of a large glycoprotein, gp91phox (PHagocyte OXidase) and a smaller protein, p22phox. Upon cell stimulation, flavocytochrome b558 assembles with p67phox, p47phox, and the GTP-binding protein Rac and becomes activated to generate O2-. Mutations in gp91phox, p22phox, or other components of the NADPH oxidase can result in chronic granulomatous disease, which is associated with significant morbidity and mortality due to a predisposition to recurrent bacterial and fungal infections.
Storage Temperature4°C
ProtocolsFCM
Clone Number7D5
Concentration0.5 mg/mL
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
D162-4
Antibody
100 uL

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