Anti-DAPK2 antibody (300-350) {FITC}

Clonality:	Polyclonal
Conjugation:	FITC
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.5-1.5 µg/µl
Dilution Range:	WB: 1:2, 500-1:5, 000 ELISA: 1:50, 000 IP: 1:200 IHC: 1:50-1:150
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	Dapk2
Gene ID:	13143
Uniprot ID:	DAPK2_MOUSE
Immunogen Region:	300-350
Immunogen:	Synthetic peptide take within amino acid region 300-350 on mouse Death-associated protein kinase 2 protein.

Tissue Specificity	Expressed in peritubular interstitial cells of the renal cortex. Isoform 1 is found in the adult brain while isoform 2 is expressed in brains of embryos and young mice (at protein level).
Post Translational Modifications	Autophosphorylation at Ser-318 inhibits its catalytic activity. Dephosphorylated at Ser-318 in response to activated Fas and TNF-alpha receptors.
Function	Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. Regulates granulocytes motility by controlling cell spreading and polarization.
Protein Name	Death-Associated Protein Kinase 2 Dap Kinase 2 Dap-Kinase-Related Protein 1 Drp-1
Cellular Localisation	Cytoplasm Cytoplasmic Vesicle Autophagosome Lumen
Alternative Antibody Names	Anti-Death-Associated Protein Kinase 2 antibody Anti-Dap Kinase 2 antibody Anti-Dap-Kinase-Related Protein 1 antibody Anti-Drp-1 antibody Anti-Dapk2 antibody

Information sourced from Uniprot.org

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