Ziprasidone [146939-27-7]
Cat# HY-14542-10mg
Size : 10mg
Brand : MedChemExpress
Ziprasidone (CP-88059), an orally active antipsychotic agent, is a combined 5-HT and dopamine receptor antagonist. Ziprasidone mesylate trihydrate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM).
For research use only. We do not sell to patients.
Ziprasidone Chemical Structure
CAS No. : 146939-27-7
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of Ziprasidone:
- Ziprasidone hydrochloride monohydrate In-stock
- Ziprasidone hydrochloride Get quote
- Ziprasidone mesylate trihydrate Get quote
- Ziprasidone mesylate Get quote
- Ziprasidone-d8 Get quote
View All 5-HT Receptor Isoform Specific Products:
View All Dopamine Receptor Isoform Specific Products:
Description |
Ziprasidone (CP-88059), an orally active antipsychotic agent, is a combined 5-HT and dopamine receptor antagonist[1]. Ziprasidone mesylate trihydrate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM)[1]. |
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IC50 & Target[1][2] |
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In Vitro |
Ziprasidone (0-500 nM, 150 seconds) blocks wild-type hERG current[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[2]
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In Vivo |
Ziprasidone (oral gavage; 20 mg/kg; once daily; 7 weeks) results in weight loss, low level physical activity, high resting energy expenditure and greater capacity for thermogenesis when subjected to cold[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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Molecular Weight |
412.94 |
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Formula |
C21H21ClN4OS |
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CAS No. |
146939-27-7 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
ClC1=CC2=C(CC(N2)=O)C=C1CCN(CC3)CCN3C4=NSC5=C4C=CC=C5 |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 13.33 mg/mL (32.28 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.81% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.4217 mL | 12.1083 mL | 24.2166 mL | 60.5415 mL |
5 mM | 0.4843 mL | 2.4217 mL | 4.8433 mL | 12.1083 mL | |
10 mM | 0.2422 mL | 1.2108 mL | 2.4217 mL | 6.0541 mL | |
15 mM | 0.1614 mL | 0.8072 mL | 1.6144 mL | 4.0361 mL | |
20 mM | 0.1211 mL | 0.6054 mL | 1.2108 mL | 3.0271 mL | |
25 mM | 0.0969 mL | 0.4843 mL | 0.9687 mL | 2.4217 mL | |
30 mM | 0.0807 mL | 0.4036 mL | 0.8072 mL | 2.0180 mL |
Ziprasidone Related Classifications
- GPCR/G Protein Neuronal Signaling
- 5-HT Receptor Dopamine Receptor