View product citations for antibody MAB22410 on CiteAb
  • Specifications

    Product Description

    Mouse monoclonal antibody raised against partial recombinant human UHRF1.MAB,monoclonal Ab,monoclonal antibody

    Immunogen

    Recombinant protein corresponding to amino acids 1-408 at the N-terminus of human UHRF1.

    Host

    Mouse

    Reactivity

    Human

    Form

    Liquid

    Conjugation

    Biotin

    Storage Buffer

    In 0.01 M Na3PO4, 0.25 M NaCl, pH 7.6 (5 mg/mL BSA, 0.02% sodium azide).

    Storage Instruction

    Store in the dark at 4°C for six months.

    Note

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

  • Applications

    Western Blot

  • Gene Info — UHRF1

    Entrez GeneID

    29128

    Protein Accession#

    Q96T88

    Gene Name

    UHRF1

    Gene Alias

    FLJ21925, ICBP90, MGC138707, Np95, RNF106, hNP95

    Gene Description

    ubiquitin-like with PHD and ring finger domains 1

    Omim ID

    607990

    Gene Ontology

    Hyperlink

    Gene Summary

    This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

    Other Designations

    E3 ubiquitin-protein ligase UHRF1|RING finger protein 106|inverted CCAAT box-binding protein of 90 kDa|nuclear zinc finger protein Np95|transcription factor ICBP90|ubiquitin-like, containing PHD and RING finger domains, 1

  • Interactomes
  • Diseases