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> Trimipramine N-oxide [14171-70-1]

Trimipramine N-oxide [14171-70-1]

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Cat# HY-147333-5mg

Size : 5mg

Brand : MedChemExpress


Trimipramine N-oxide is an active metabolite of the tricyclic antidepressant trimipramine. Trimipramine N-oxide inhibits the human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT) and the human organic cation transporters (hOCT1 and hOCT2) with IC50s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM, respectively. Trimipramine N-oxide can be used for the research of depression and anxiety.

For research use only. We do not sell to patients.

Trimipramine N-oxide Chemical Structure

Trimipramine N-oxide Chemical Structure

CAS No. : 14171-70-1

This product is a controlled substance and not for sale in your territory.

Based on 1 publication(s) in Google Scholar

Description

Trimipramine N-oxide is an active metabolite of the tricyclic antidepressant trimipramine. Trimipramine N-oxide inhibits the human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT) and the human organic cation transporters (hOCT1 and hOCT2) with IC50s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM, respectively. Trimipramine N-oxide can be used for the research of depression and anxiety[1].

IC50 & Target

IC50: 3.59 nM (hSERT), 9.35 nM (hOCT1), 9.4 nM (hDAT), 11.7 nM (hNAT), 27.4 (hOCT2)[1]
In Vitro

Trimipramine N-oxide (0-30 μM; 48 h) inhibits hNAT, hSERT, hDAT, hOCT1 and hOCT2 in HEK293 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trimipramine N-oxide Related Antibodies

Cell Viability Assay[1]

Cell Line: HEK293 cells
Concentration: 0-30 μM
Incubation Time: 48 hours
Result: Dose-dependently inhibited hNAT, hSERT, hDAT, hOCT1 and hOCT2 with IC50s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM in HEK293 cells, respectively.
Molecular Weight

310.43

Formula

C20H26N2O
CAS No.

14171-70-1
SMILES

[O-][N+](C)(CC(CN1C2=C(CCC3=C1C=CC=C3)C=CC=C2)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References

  • [1]. Haenisch B, et al. Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters. Psychopharmacology (Berl). 2011 Sep;217(2):289-95.  [Content Brief]

  • [1]. Haenisch B, et al. Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters. Psychopharmacology (Berl). 2011 Sep;217(2):289-95.

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Trimipramine N-oxide Related Classifications

  • Metabolic Enzyme/Protease
  • Drug Metabolite

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trimipramine N-oxide14171-70-1Drug Metaboliteactive metabolitehuman monoamine transporterhuman organic cation transportertrimipramineInhibitorinhibitorinhibit