Thiocolchicine-d3 [1314417-95-2]
Cat# HY-116852S-5mg
Size : 5mg
Brand : MedChemExpress
Thiocolchicine-d3 is deuterium labeled Thiocolchicine. Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC50=2.5 µM) and competitively binds to tubulin with a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis[1][2]. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.
For research use only. We do not sell to patients.
Thiocolchicine-d3 Chemical Structure
CAS No. : 1314417-95-2
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of Thiocolchicine-d3:
- Thiocolchicine In-stock
Description |
Thiocolchicine-d3 is deuterium labeled Thiocolchicine. Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC50=2.5 µM) and competitively binds to tubulin with a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis[1][2]. Thiocolchicine can be used as an ADC cytotoxin in ADC technology. |
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In Vitro |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molecular Weight |
418.52 |
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Formula |
C22H22D3NO5S |
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CAS No. |
1314417-95-2 |
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Unlabeled CAS |
2730-71-4 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=C(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(SC)C2=O)C([2H])([2H])[2H] |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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Solvent & Solubility |
In Vitro:
DMSO : 100 mg/mL (238.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) DMSO : 100 mg/mL (238.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
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Purity & Documentation |
Purity: ≥99.0% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO / DMSO | 1 mM | 2.3894 mL | 11.9469 mL | 23.8937 mL | 59.7343 mL |
5 mM | 0.4779 mL | 2.3894 mL | 4.7787 mL | 11.9469 mL | |
10 mM | 0.2389 mL | 1.1947 mL | 2.3894 mL | 5.9734 mL | |
15 mM | 0.1593 mL | 0.7965 mL | 1.5929 mL | 3.9823 mL | |
20 mM | 0.1195 mL | 0.5973 mL | 1.1947 mL | 2.9867 mL | |
25 mM | 0.0956 mL | 0.4779 mL | 0.9557 mL | 2.3894 mL | |
30 mM | 0.0796 mL | 0.3982 mL | 0.7965 mL | 1.9911 mL | |
40 mM | 0.0597 mL | 0.2987 mL | 0.5973 mL | 1.4934 mL | |
50 mM | 0.0478 mL | 0.2389 mL | 0.4779 mL | 1.1947 mL | |
60 mM | 0.0398 mL | 0.1991 mL | 0.3982 mL | 0.9956 mL | |
80 mM | 0.0299 mL | 0.1493 mL | 0.2987 mL | 0.7467 mL | |
100 mM | 0.0239 mL | 0.1195 mL | 0.2389 mL | 0.5973 mL |
Thiocolchicine-d3 Related Classifications
- Cancer
- Cancer Targeted Therapy Cancer Metabolism and Metastasis
- Cell Cycle/DNA Damage Cytoskeleton Apoptosis
- Microtubule/Tubulin Apoptosis
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Keywords:
Thiocolchicine-d31314417-95-2Microtubule/TubulinApoptosisInhibitorinhibitorinhibit