Western Blot (Cell lysate)
Western blot analysis of TARDBP in HeLa whole cell extract with TARDBP polyclonal antibody (Cat # PAB12006).
- Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TARDBP.
Immunogen
A synthetic peptide corresponding to amino acids 350-414 of human TARDBP.
Host
Rabbit
Reactivity
Chicken, Human, Mouse, Primates, Xenopus, Zebra fish
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-glycine, 150 mM NaCl (0.05% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
Western Blot (Cell lysate)
Western blot analysis of TARDBP in HeLa whole cell extract with TARDBP polyclonal antibody (Cat # PAB12006). - Gene Info — TARDBP
Entrez GeneID
23435Protein Accession#
Q13148Gene Name
TARDBP
Gene Alias
ALS10, TDP-43
Gene Description
TAR DNA binding protein
Omim ID
605078Gene Ontology
HyperlinkGene Summary
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq
Other Designations
OTTHUMP00000002171|TAR DNA-binding protein-43
- Interactomes
- Diseases
- Publication Reference
- Reduced cellular Ca2+ availability enhances TDP-43 cleavage by apoptotic caspases.
De Marco G, Lomartire A, Mandili G, Lupino E, Buccinna B, Ramondetti C, Moglia C, Novelli F, Piccinini M, Mostert M, Rinaudo MT, Chio A, Calvo A.
Biochimica et Biophysica Acta 2014 Apr; 1843(4):725.
Application：WB-Re, Recombinant protein.
- Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis.
Geser F, Brandmeir NJ, Kwong LK, Martinez-Lage M, Elman L, McCluskey L, Xie SX, Lee VM, Trojanowski JQ.
Archives of Neurology 2008 May; 65(5):636.
Application：IF, IHC-P, Human, Brain and spinal cord from patients with amyotrophic lateral sclerosis.
- TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions.
Cairns NJ, Neumann M, Bigio EH, Holm IE, Troost D, Hatanpaa KJ, Foong C, White CL 3rd, Schneider JA, Kretzschmar HA, Carter D, Taylor-Reinwald L, Paulsmeyer K, Strider J, Gitcho M, Goate AM, Morris JC, Mishra M, Kwong LK, Stieber A, Xu Y, Forman MS, Trojanowski JQ, Lee VM, Mackenzie IR.
The American Journal of Pathology 2007 Jul; 171(1):227.
Application：IEM, IHC-P, WB, Human, Human brain.
- Reduced cellular Ca2+ availability enhances TDP-43 cleavage by apoptotic caspases.