Tardbp Mouse shRNA Plasmid (Locus ID 230908)
Cat# TR506908
Size : 1kit
Tardbp Mouse shRNA Plasmid (Locus ID 230908)
SKU
TR506908
Tardbp - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
In Stock*
| Product Data | |
| Locus ID | 230908 |
|---|---|
| Synonyms | 1190002A23Rik; C85084; TDP-43; Tdp43 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Format | Retroviral plasmids |
| Components | Tardbp - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 230908). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | BC012873, BC025544, BC027105, BC027772, BC029728, BC031126, BC033475, NM_001003898, NM_001003899, NM_001008545, NM_001008546, NM_001305425, NM_145556, NR_027864, NR_131120, NR_149751, NM_001003899.1, NM_001003899.2, NM_145556.1, NM_145556.2, NM_145556.3, NM_145556.4, NM_001003898.1, NM_001003898.2, NM_001003898.3, NM_001008545.1, NM_001008545.2, NM_001008546.1, NM_001008546.2 |
| UniProt ID | Q921F2 |
| Summary | RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3' UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3' UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival. Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins. Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980).[UniProtKB/Swiss-Prot Function] |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact tech@biotrend-usa.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Write Your Own Review
| Product Manuals |
|
| FAQs |
|
| SDS |
| RNAi Resources |
|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.