Size : 100 mg
| Soluble in DMSO at 100 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-30 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility VX-680 (also known as Tozasertib) is a potent inhibitor of all aurora kinases, including the A, B and C isotypes (Ki = 0.6 nM, 18 nM and 4.6 nM, respectively). It also inhibits ABL kinase (Ki = 30 nM), an imatinib-resistant ABL mutant (T315I) kinase (Ki = 42 nM), and Flt-3 (Ki = 30 nM). Tozasertib binds to an inactive aurora conformation. Cheetham, G.M., et al. "Structural basis for potent inhibition of the aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680." Cancer Lett. 251: 323-329 (2007). |
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