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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human brain cortex with STX1A polyclonal antibody (Cat # PAB28370). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

View product citations for antibody PAB28370 on CiteAb
  • Specifications

    Product Description

    Rabbit polyclonal antibody raised against synthetic peptide of STX1A.PAB,polyclonal Ab,polyclonal antibody

    Immunogen

    A synthetic peptide corresponding to 15 amino acids at N-Terminus of human STX1A.

    Host

    Rabbit

    Reactivity

    Hamster, Human, Monkey, Mouse, Pig, Rat

    Specificity

    BLAST analysis of the peptide immunogen showed no homology with other human proteins, except STX2 (67%).

    Form

    Liquid

    Purification

    Immunoaffinity chromatography

    Recommend Usage

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/ml)
    The optimal working dilution should be determined by the end user.

    Storage Buffer

    In PBS (0.09% sodium azide)

    Storage Instruction

    Store at 4°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.

    Note

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

  • Applications

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human brain cortex with STX1A polyclonal antibody (Cat # PAB28370). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
  • Gene Info — STX1A

    Entrez GeneID

    6804

    Protein Accession#

    Q16623

    Gene Name

    STX1A

    Gene Alias

    HPC-1, STX1, p35-1

    Gene Description

    syntaxin 1A (brain)

    Omim ID

    186590

    Gene Ontology

    Hyperlink

    Gene Summary

    Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM

    Other Designations

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