Stemolecule™ LDN-193189
04-0074 / 04-0074-10 / 04-0074-02
Brand: Stemolecule™
LDN193189 is a cell permeable, small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3.
CAS Number: 1062368-24-4
Alternate Name(s):
- LDN193189
- 4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline hydrochloride
Currency:
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Product Information
04-0074 Specifications Sheet 04-0074-10 Specifications Sheet 04-0074-02 Specifications Sheet
Safety Data Sheets:
- Yu, P.B., Deng, D.Y., Lai, C.S., Hong, C.C., Cuny, G.D., Bouxsein, M.L., Hong, D.W., McManus, P.M., Katagiri, T., Sachidanandan, C., Kamiya, N., Fukuda, T., Mishina, Y., Peterson, R.T., and Bloch, K.D. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med 14: 1363-1369 (2008).
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- Cuny, G.D., Yu, P.B., Laha, J.K., Xing, X., Liu, J.F., Lai, C.S., Deng, D.Y., Sachidanandan, C., Bloch, K.D., and Peterson, R.T. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett 18: 4388-4392 (2008).
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Additional Publications
- Wang M; Li W; Hao J; Conzales A; Zhao Z; Flores RS; Kuang X; Mu X; Ching T; Tang G; Luo Z; Garciamendez-Mijares EC; Sahoo JK; Wells MF; Niu G; Agrawal P; Quiñonoes-Hinojosa A; Eggan K; Zhang YS. Molecularly cleavable bioinks facilitate high-performance digital light processing-based bioprinting of functional volumetric soft tissues. Nature Commun 13:3317 (2022).
- Nie J; Ueda Y; Solivais AJ; Hashino E. CHD7 regulates otic lineage specification and hair cell differentiation in human inner ear organoids. Nature Commun 13:7053 (2022).
- Takao T; Yamada D; Takarda T. A protocol to induce expandable limb-bud mesenchymal cells from human pluripotent stem cells. Star Protocols 3:101786 (2022).
- Cohen B; McPhie D; Ren B; Garcia-Leon J; Verfaille C. SOX10 Expression Levels may be a Critical Mediator of White Matter Deficits in Schizophrenia. BioRivX https://doi.org/10.21203/rs.3.rs-1808873/v1: (2022).
- Gonzàlez BJ; Zhao H; Niu J; Williams DJ; Lee J; Goulbourne CN' Xing Y; Wang Y' Oberholzer J; Blumenkrantz MH; Chen X; LeDuc CA; Chung WK; Colecraft HM; Gromada J; ShenY; Goland RS; Leibel RL; Egli D. Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency. Commun Biology 5:779 (2022).
- Liang L ;Tian Y; Feng L; Wang C; Feng G; Stacey GN; Shyh-Change N; Wu J; Hu B; Li W: Hao J; Wang L; Wang Y. Single-cell transcriptomics reveals the cell fate transitions of human dopaminergic progenitors derived from hESCs. Stem Cell Res Therap 13:412 (2022).
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- Budjan C; Liu S; Ranga A; Gayen S; Pourquiè. Paraxial mesoderm organoids model development of human somites. eLife 11:e68925 (2022).
- Li Z; Lui KN-C; Lau S-T; Lai FP-L; Li P; Chung P; Wong K; Tam P; Cracia-Barcelo M-M; Hui C-c; Sham P; Ngan E. Hedgehog-induced-oxidative-phosphorylation rescues neuronal differentiation defect of human enteric neural crest cells underlying Hirschsprung disease. Research Square :doi.org/10.21203/rs.3.rs-1433241/v1 (2022).
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- Wen J; Song J; Bai Y; Liu T; Cai X; Mei L ;Ma L ; He C; Feng Y. A Model of Waardenburg Syndrome Using Patient-Derived iPSCs With a SOX10 Mutation Displays Compromised Maturation and Function of the Neural Crest That Involves Inner Ear Development. Front Cell Dev Biol 9:720858 (2022).
- Lu V. The Role of Glutamine in Primed Human Pluripotent Stem Cell Fate. Ph.D. Theses, University of California, Los Angeles : (2022).
- Adachi H; Morizane A; Torikoshi S; Raudzus F; Taniguchi Y; Miyamoto S; Sekiguchi K; Takahashi J. Pretreatment with Perlecan-Conjugated Laminin-E8 Fragment Enhances Maturation of Grafted Dopaminergic Progenitors in Parkinson’s Disease Model. Stem Cell Transl Med 11:767 (2022).
- Khoury-Beaumont N; Prakasam R; Pondugula S; Lagas JS; Matkovich S; Gontarz P' Yang L; Yano H; Kim AH; Rubin JB; Kroll KL. The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential. BMC Biology 20:124 (2022).
- Habekost M; Qvist P; Denham M; Holm IE; Jørgensen AL. Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration. Molecular Neurobiol 176:1 (2021).
- Sakota, S; Shimokawa F; Funaba M; Murakami M. Isolation of the canine inhibinβB subunit gene and characterization of signalling mediated by canine inhibin βB. Cell Biochem Function 2021:1 (2021).
- Parent AV; Faleo G; Chavez J; Saxton M; Berrios DI; Kerper NR; Tang Q; Hebrok M. Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection. Cell Rep 36:109538 (2021).
- Nakajima T; Nakahata A; Yamada N; Yoshizawa K; Kato TM; Iwassaki M; Zhao C; Kuroki H; Ikeya M. Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture. Nature Commun 37:5012 (2021).
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- Khalili M; Zarebkohan A; Dianat-Moghadam H; Panahi M; Andre H; Alizadeh E. Corneal endothelial cell sheet bioengineering from neural crest cell-derived adipose stem cells on novel thermo-responsive elastin-mimetic dendrimers decorated with RGD. Chem Engr J 429:132523 (2022).
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- Seo BA; Kim D; Hwang H; Kim MS; Ma S-H; Kweon SH; Wang J; Yoo JM; Choi S; Kwon SH; Kange S-U; Kam T-I; Kim K; Karuppagounder SS; Kang BG; Lee S; Park H; Kim S; Yan W; Li YS; Kuo SH; Redding-Ochoa J; Pletnikova O; Troncosco JC; Lee G' Mao X; Dawson VL; Dawson TM; Ko HS. TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson’s disease. Neuron 23:3753-74.e11 (2021).
- Xi N; Wu J; Ortiz-Vitali JL; Li Y; Darabi R. Directed Differentiation of Human Pluripotent Stem Cells toward Skeletal Myogenic Progenitors and Their Purification Using Surface Markers. Cells 10:2746 (2021).
- Fernandes HJR; Patikas M; Foskolou S; Field SF; Park J-E; Myrne ML; Bassett AR; Metzakopian E. Single-Cell Transcriptomics of Parkinson’s Disease Human In Vitro Models Reveals Dopamine Neuron-Specific Stress Responses. Cell Reports 33:108263 (2020).
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- Habekost M; Jørgensen AL; Qvist P; Denham M. MicroRNAs and Ascl1 facilitate direct conversion of porcine fibroblasts into induced neurons. Stem Cell Res 48:101984 (2020).
- von Troyer M. Establishment of an alginate based 3D culture system for the generation of dopaminergic neurons. Masters Thesis, Univ Innsbruck : (2020).
- Susco SG; Arias-Garçia MA; López-Huerta VG; Beccard A; Bara AM; Moffitt J; Korn J; Fu Z; Barrett LE. FMR1 loss in a human stem cell model reveals early changes to intrinsic membrane excitability. Develop Biol 468:93-100 (2020).
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- Mazzara PG; Muggeo S; Luoni M; Massimino L Zaghi M; Valverde PT-T; Brusco S: Marzi MJ; Palma C; Colasante G; Iannielli A; Paulis M; Cordiglieri C;: Giannelli SG; Podini P; Gellera C; Taroni F; Nicassio F; Rasponi M; Broccoli V. Frataxin gene editing rescues Friedreich’s ataxia pathology in dorsal root ganglia organoid-derived sensory neurons. Nature Commun 11:4178 (2020).
- Sook SR; Badell-Grau RA; Kirkham ED; Jones KM; Kelly BP; WInston J; Waller-Evans H; Allen ND; Lloyd-Evans E. Detrimental effect of zwitterionic buffers on lysosomal homeostasis in cell lines and iPSC-derived neurons. AMRC Open Res 2:21 (2020).
- Angelova PR; Choi ML; Berezhnov AV; Horrocks MH; Hughes CD; De S; Redrigues M; Yapom R; Little D; Dolt KS; Kunath T; Devine MJ; Gissen P; Shchepinov MS; Sylantyev S; Pavlov EV; Klenerman D; Abramov AY; Handhi S'. Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation. Cell Death Differ :doi.org/10.1038/s41418-020-0542-z (2020).
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- Ahfeldt T; Ordureau A; Bell C; Sarrafha L; Sun C; Piccinotti S; Crass T; Parfitt GM; Paulo JA; Yanagawa J; Uozumi T; Kiyota Y; Harper JW' Rubin LL. Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons. Stem Cell Rep in press:doi.org/10.1016/j.scemcr.2019.12.005 (2020).
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- Matsumoto R; Suga H; Aoi T; Bando H; Fukuoka H; Iguchi G; Narumi S; Hasegawa T; Muguruma K; Ogawa W; Takahashi Y. Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells. J Clin Investigation in press:doi.org/10.1172/JCI127378 (2019).
- Gantner CWB. Investigating Brain Repair and Development Using Stem Cells. Ph. D. Thesis, University of Melbourne : (2019).
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- Koutmani Y; Gampierakis IA; Polissidis A; Ximerakis M: Koutsoudaki PN; Polyzos A; Agrogiannis G; Karaliota S; Thomaidou D; Rubin LL; Politis PK; Karakis KP. CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus. Stem Cell Rep 28:932-945.e7 (2019).
- Leitner D; Ramamoorthy M; Dejosez M; Zwaka TP. Immature mDA Neurons Ameliorate Motor Deficits in a 6-OHDA Parkinson's Disease Mouse Model and are Functional after Cryopreservation. Stem Cell Res in press:doi.org/10.1016/j.scr.2019.101617 (2019).
- Nagaraja S; Quezada MA; Gillespie SM; Arzt M; Lennon JJ; Woo PJ; Hovestadt V; Kambhampati M; Filbin MG; Suva ML; Nazarian J; Monje M. Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State. Molecular Cell 76:1-16 (2019).
- Ortiz-Vitali J. iPSC based gene correction and disease model of a new class of LGMD due to POGLUT1 mutation. Master's Thesis Univ of Texas: (2019).
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- Lee K; Cho H; Rickert RW; Li QV; Pulecia J; Leslie CS; Huangfu D. FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation. Cell Reports 28:382-393 (2019).
- Lindsay CD; Roth JG; LeSafage BL; Heilshorn SC. Bioprinting of stem cell expansion lattices. Acta Biomaterialia in press:doi.org/10.1016/j.actbio.2019.05.014 (2019).
- Govier-Cole AE; Wood RJ; Fletcher JL; Gonsalvez DF; Merlo D; Cate HS; Murray SS; Xiao J. Inhibiting bone morphogenetic protein 4 type I receptor signaling promotes remyelination by potentiating oligodendrocyte differentiation. eNeuro :ENEURO.0399-18.2019 (2019).
- Freedman DA. The impact of environmental and genetic insults on adult and developing brain oligodendrogenesis. Doctoral Thesis, University of Buffalo : (2019).
- Graß T. Modeling familial Alzheimer's disease utilizing gene targeted human induced pluripotent stem cells. Doctoral Thesis, Freie Univerität Berlin : (2018).
- Harmanto Y; Maki T; Yakagi Y; Miyamoto S; Takahashi J. Xeno‐free culture for generation of forebrain oligodendrocyte precursor cells from human pluripotent stem cells. J Neuro Res 2019:1-18 (2019).
- Qadir MMF; Álvarez-Cubela S; Belle K; Sapir T; Messaggio F; Johnson KB; Umland O; Hardin D; Klein D; Pérez-Álvarez I; Fraker CA; Pastori RL Domínguez-Bendalla J. A Double Fail-Safe Approach to Prevent Tumorigenesis and Select Pancreatic β Cells from Human Embryonic Stem Cells. Stem Cell Rep 3:611-623 (2019).
- Wadhwani AR; Affaneh A; Van Gulden S; Kessler JA. Neuronal Apolipoprotein E4 increases cell death and p‐tau release in Alzheimer's disease. Ann Neurol doi: 10.1002/ana.25455.: (2019).
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- Wang L; De Solis AJ; Goffer Y; Birkenback KE; Engle SE; Tanis R; Levenson JM; Lu X; Rausch R: Purohit M; Lee J-Y; Tan J; De Rosa MC; DOege CA; Aaron HL; Martins G; Brüning JC; Egli D; Costa R; Berbari N; Leibel RL; Stratigopoulos G. Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development. JCI Insight 4:e123337 (2019).
- Chuang C-Y; Yand C-C; Soong B-W; Yu C-C; Chen S-H; Huang H-P; Kuo H-C. Modeling spinocerebellar ataxias 2 and 3 with iPSCs reveals a role for glutamate in disease pathology. Sci Rep 9:1166 (2019).
- van Rhijn, J-R. The role of FOXP2 in striatal circuitry. Ph.D. Thesis, Radboud University Nijmegen : (2019).
- Rajaei B; Massumi M; Wheeler M. Glucose‐Responsiveness of Pancreatic β‐Like (GRP β‐L) Cells Generated from Human Pluripotent Stem Cells. Current Protoclos Human Genetics 100:e71 (2019).
- Duong TT; Lim J; Vasireddy V; Papp T; Nguyen H; Leo L; Pan J; Zhou S; Chen HI; Bennet J; Mills JA. Comparative AAV-eGFP Transgene Expression Using Vector Serotypes 1–9, 7m8, and 8b in Human Pluripotent Stem Cells, RPEs, and Human and Rat Cortical Neurons. Stem Cells Int:Article ID: 7281912 (2019).
- Ma S; Viola R: Sui L; Cherubini V; Barbetti F; Eigli D. β Cell Replacement after Gene Editing of a Neonatal Diabetes-Causing Mutation at the Insulin Locus. Stem Cell Reports https://doi.org/10.1016/j.stemcr.2018.11.006: (2018).
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- Sun X; Song J; Huang H; Chen H; Qian K. Modeling hallmark pathology using motor neurons derived from the family and sporadic amyotrophic lateral sclerosis patient-specific iPS cells. Stem Cell Res Therapy 9:315 (2018).
- Javed AO; Li Y; Muffat J; Su K-C; Cohen MA; Lungjangwa T; Auborg P; Cheeseman IM; Jaenisch R. Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype. Cell Rep 25:368-382.e5 (2018).
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