SMC6L1 (SMC6) Human shRNA Plasmid Kit (Locus ID 79677)
Cat# TL301502
Size : 1kit
SMC6L1 (SMC6) Human shRNA Plasmid Kit (Locus ID 79677)
SKU
TL301502
SMC6 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
In Stock*
| Product Data | |
| Locus ID | 79677 |
|---|---|
| Synonyms | hSMC6; SMC-6; SMC6L1 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Format | Lentiviral plasmids |
| Components | SMC6 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 79677). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | NM_001142286, NM_024624, NM_024624.1, NM_024624.2, NM_024624.3, NM_024624.4, NM_024624.5, NM_001142286.1, BC039828, BC039828.1, BC011389, BC022998, BC032675, NM_001142286.2 |
| UniProt ID | Q96SB8 |
| Summary | Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).[UniProtKB/Swiss-Prot Function] |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact tech@biotrend-usa.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.