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> Remdesivir nucleoside monophosphate [1911578-74-9]

Remdesivir nucleoside monophosphate [1911578-74-9]

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Cat# HY-44358-1mg

Size : 1mg

Brand : MedChemExpress


Remdesivir nucleoside monophosphate is a metabolite of Remdesivir. Remdesivir is a nucleoside analogue with effective antiviral activity against SARS-CoV and MERS-CoV.

For research use only. We do not sell to patients.

Remdesivir nucleoside monophosphate Chemical Structure

Remdesivir nucleoside monophosphate Chemical Structure

CAS No. : 1911578-74-9

This product is a controlled substance and not for sale in your territory.

Based on 3 publication(s) in Google Scholar

Description

Remdesivir nucleoside monophosphate is a metabolite of Remdesivir[1]. Remdesivir is a nucleoside analogue with effective antiviral activity against SARS-CoV and MERS-CoV[2].

Molecular Weight

371.24

Formula

C12H14N5O7P
CAS No.

1911578-74-9
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@](C#N)(C2=CC=C3C(N)=NC=NN32)O[C@@H]1COP(O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (67.34 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6937 mL 13.4684 mL 26.9368 mL
5 mM 0.5387 mL 2.6937 mL 5.3874 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.98%

COA (255 KB) RP-HPLC (244 KB)

Handling Instructions (2659 KB)
References

  • [1]. Byoung Kwon Chun, et al. or treating filoviridae virus infections. US20160122374.

    [2]. Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(2). pii: e00221-18.  [Content Brief]

  • [1]. Byoung Kwon Chun, et al. or treating filoviridae virus infections. US20160122374.

    [2]. Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(2). pii: e00221-18.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6937 mL 13.4684 mL 26.9368 mL 67.3419 mL
5 mM 0.5387 mL 2.6937 mL 5.3874 mL 13.4684 mL
10 mM 0.2694 mL 1.3468 mL 2.6937 mL 6.7342 mL
15 mM 0.1796 mL 0.8979 mL 1.7958 mL 4.4895 mL
20 mM 0.1347 mL 0.6734 mL 1.3468 mL 3.3671 mL
25 mM 0.1077 mL 0.5387 mL 1.0775 mL 2.6937 mL
30 mM 0.0898 mL 0.4489 mL 0.8979 mL 2.2447 mL
40 mM 0.0673 mL 0.3367 mL 0.6734 mL 1.6835 mL
50 mM 0.0539 mL 0.2694 mL 0.5387 mL 1.3468 mL
60 mM 0.0449 mL 0.2245 mL 0.4489 mL 1.1224 mL
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Remdesivir nucleoside monophosphate Related Classifications

  • Cell Cycle/DNA Damage Anti-infection Metabolic Enzyme/Protease
  • DNA/RNA Synthesis SARS-CoV Drug Metabolite
Help & FAQs

Keywords:

Remdesivir nucleoside monophosphate1911578-74-9DNA/RNA SynthesisSARS-CoVDrug MetaboliteSARS coronavirusInhibitorinhibitorinhibit