Recombinant Human Interleukin 13 Receptor, Alpha 1 (IL-13 Rα1)

Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1 (cluster of differentiation 213A1) is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. IL13Ralpha1is essential for allergeninduced airway hyperreactivity and mucus hypersecretion.¹

The biological activity of Human IL13 Rα1 was determined by its binding ability in a functional ELISA.

Ala27

Lyophilized

The predicted molecular weight of Recombinant Human IL13 Rα1 is Mr 64 kDa. However, the actual molecular weight as observed by migration on SDSPAGE is Mr 110 kDa.

64

This lyophilized protein is stable for six to twelve months when stored desiccated at 20°C to 70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at 20°C to 70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Caput, D. et al. (1996) J. Biol. Chem. 271:16921
2. Donaldson, DD. et al. (1998) J. Immunol. 161:2317
3. Hilton, DJ. et al. (1996) Proc. Natl. Acad. Sci. (USA) 93:497
4. Zhang, JG. et al. (1997) J. Biol. Chem. 272:9474
5. Orchansky, PL. et al. (1999) J. Biol. Chem. 274:0818