Recombinant Human CCL25

Chemokine (CC motif) ligand 25 (CCL25) is a small cytokine belonging to the CC chemokine family that is also known as TECK (ThymusExpressed ChemoKine). CCL25 is believed to play a role in the development of Tcells.¹ It is chemotactic for thymocytes, macrophages, and dendritic cells. CCL25 is expressed in the small intestinal epithelium and plays an important role in mediating lymphocyte recruitment to this site.² CCL25 is also highly expressed in the thymus, where it binds to its receptor CCR9 on thymocytes promoting migration and activation.³

The biological activity of Human ThymusExpressed Chemokine is determined by its ability to chemoattract human monocytes using a concentration range of 1.010.0 ng/ml.

AAB69981.1

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Gln24

Lyophilized

The predicted molecular weight of Recombinant Human CCL25 is Mr 14 kDa. Additionally, the actual molecular weight as observed by migration on SDSPAGE is Mr 14 kDa.

14

This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH₃CN) and 0.1% trifluoroacetic acid (TFA).

This lyophilized protein is stable for six to twelve months when stored desiccated at 20°C to 70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at 20°C to 70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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1. Zlotnik, A. et al. (1997) Immunity. 7(2):291301.
2. Agace, W. et al. (2006) J Immunol. 176:3642
3. Teixidó, J. et al. (2007) J Leukoc Biol. 82:380