Picroside I [27409-30-9]
Cat# HY-N0407-10mg
Size : 10mg
Brand : MedChemExpress
Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II. Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ.
For research use only. We do not sell to patients.
Picroside I Chemical Structure
CAS No. : 27409-30-9
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of Picroside I:
- Picroside I (Standard) Get quote
View All STAT Isoform Specific Products:
| Description |
Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II[1]. Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ[2]. |
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| IC50 & Target[2] |
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| In Vivo |
Picroside I (20 mg/kg, o.p, 12 d) reduces AHR in the experimental asthma model and reduces OVA-associated IgE levels[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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| Molecular Weight |
492.47 |
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| Formula |
C24H28O11 |
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| CAS No. |
27409-30-9 |
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| Appearance |
Solid |
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| Color |
White to off-white |
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| SMILES |
OC[C@]12[C@@H](O2)[C@@H](O)[C@@]3(09)[C@]1(09)[C@H](O[C@]4(09)O[C@H](COC(/C=C/C5=CC=CC=C5)=O)[C@@H](O)[C@H](O)[C@H]4O)OC=C3 |
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| Structure Classification |
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| Initial Source |
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| Shipping | Room temperature in continental US; may vary elsewhere. |
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| Storage |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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| Solvent & Solubility |
In Vitro:
DMSO : 250 mg/mL (507.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : 116.67 mg/mL (236.91 mM; Need ultrasonic) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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| Purity & Documentation |
Purity: 99.55% COA (251 KB) HNMR (407 KB) RP-HPLC (121 KB) Handling Instructions (2659 KB) |
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| References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O / DMSO | 1 mM | 2.0306 mL | 10.1529 mL | 20.3058 mL | 50.7645 mL |
| 5 mM | 0.4061 mL | 2.0306 mL | 4.0612 mL | 10.1529 mL | |
| 10 mM | 0.2031 mL | 1.0153 mL | 2.0306 mL | 5.0765 mL | |
| 15 mM | 0.1354 mL | 0.6769 mL | 1.3537 mL | 3.3843 mL | |
| 20 mM | 0.1015 mL | 0.5076 mL | 1.0153 mL | 2.5382 mL | |
| 25 mM | 0.0812 mL | 0.4061 mL | 0.8122 mL | 2.0306 mL | |
| 30 mM | 0.0677 mL | 0.3384 mL | 0.6769 mL | 1.6922 mL | |
| 40 mM | 0.0508 mL | 0.2538 mL | 0.5076 mL | 1.2691 mL | |
| 50 mM | 0.0406 mL | 0.2031 mL | 0.4061 mL | 1.0153 mL | |
| 60 mM | 0.0338 mL | 0.1692 mL | 0.3384 mL | 0.8461 mL | |
| 80 mM | 0.0254 mL | 0.1269 mL | 0.2538 mL | 0.6346 mL | |
| 100 mM | 0.0203 mL | 0.1015 mL | 0.2031 mL | 0.5076 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Picroside I Related Classifications
- Inflammation/Immunology
- JAK/STAT Signaling Stem Cell/Wnt
- STAT