PDI Polyclonal Antibody
Cat# bs-1476R-20ul
Size : 20ul
Brand : Bioss
PDI Polyclonal Antibody
Applications
Reactivity
Predicted Reactivity
Overview | |
Catalog # | bs-1476R |
Product Name | PDI Polyclonal Antibody |
Applications | WB, ELISA, IHC-P, IHC-F, IF(IHC-P), IF(IHC-F), IF(ICC) |
Reactivity | Human, Mouse |
Predicted Reactivity | Rat, Cow, Horse, Chicken, Rabbit |
Specifications | |
Conjugation | Unconjugated |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human PDI |
Immunogen Range | 21-150/508 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Storage Condition | Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Target | |
Gene ID | 5034 |
Swiss Prot | P07237 |
Subcellular location | Cytoplasm |
Synonyms | Protein Disulfide lsomerase; Cellular thyroid hormone-binding protein; PDI; Prolyl 4-hydroxylase subunit beta; p55; P4HB; ERBA2L; P4HB; ERBA2L; PDIA1; PO4DB; PDIA1_HUMAN. |
Background | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). |
Application Dilution | |
WB | 1:300-5000 |
ELISA | 1:500-1000 |
IHC-P | 1:200-400 |
IHC-F | 1:100-500 |
IF(IHC-P) | 1:50-200 |
IF(IHC-F) | 1:50-200 |
IF(ICC) | 1:50-200 |