NeuroD1 (1C9) Monoclonal Antibody

Cat# bsm-52948R

Size : 100ul

Brand : Bioss


NeuroD1 (1C9) Monoclonal Antibody

Applications

  • WB
  • IHC-P

Reactivity

  • Human
  • Mouse
  • Rat
Overview
Catalog # bsm-52948R
Product Name NeuroD1 (1C9) Monoclonal Antibody
Applications WB, IHC-P
Reactivity Human, Mouse, Rat
Specifications
Conjugation Unconjugated
Host Rabbit
Source N terminal human NeuroD1
Immunogen Range 1-50/356
Clonality Monoclonal
Clone # 1C9
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 4760
Swiss Prot Q13562
Subcellular location Nucleus
Synonyms Neurogenic differentiation factor 1; Class A basic helix-loop-helix protein 3; NeuroD; NeuroD1; bHLHa3; NEUROD1; BETA2; BHF-1; MODY6.
Background Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis.
Application Dilution
WB 1:300-5000
IHC-P 1:200-400

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