Navitoclax (ABT 263)

Cat# 285063-250mg

Size : 250mg

Brand : US Biological



285063 Rabbit Anti-Navitoclax (ABT 263)

Clone Type
Polyclonal
Grade
Highly Purified
Shipping Temp
RT
Storage Temp
-20°C

A novel inhibitor of antiapoptotic BCL-2 proteins; a new promising anticancer drug candidate. Potent Bcl-2 family inhibitor.||Synonyms:|4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide; Navitoclax| |CAS NO:|923564-51-6||Molecular Formula:|C₄₇H₅₅ClF₃N₅O₆S₃||Molecular Weight:|974.61||Purity:|≥98%||Appearance:|Pale yellow to pale brown solid||Melting Point:|>124°C (dec.)||Solubility:|DMSO (slightly), Methanol (slightly)||Method for Determining Identity: |Proton NMR (DMSO-d6), 19F NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis||Atmosphere:|Inert gas||Ethyl Acetate Content:|~2.5%||Storage and Stability:|Powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Hygroscopic. Note: Inert atmosphere is preferred for long term storage.

Applications
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. ||Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Form
Pale yellow to pale brown solid
Purity
≥98%
References
1. Adams, J., et al.: Science, 281:1322 (1998), 2. Degterev, A., et al.: Nat. Cell. Biol., 3:173 (2001), 3. Kitada, S., et al.: J. Med. Chem., 46:4259 (2003), 4. Danial, N., et al.: Clin. Cancer Res., 13:7254 (2007)

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