N-desmethyl Enzalutamide [1242137-16-1]
Cat# HY-70002A-10mg
Size : 10mg
Brand : MedChemExpress
N-desmethyl Enzalutamide is the active metabolite of Enzalutamide.N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide.
For research use only. We do not sell to patients.
N-desmethyl Enzalutamide Chemical Structure
CAS No. : 1242137-16-1
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of N-desmethyl Enzalutamide:
- Enzalutamide In-stock
- N-desmethyl Enzalutamide-d6 In-stock
- Enzalutamide carboxylic acid In-stock
Description |
N-desmethyl Enzalutamide is the active metabolite of Enzalutamide.N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide[1]. |
IC50 & Target |
Androgen-receptor[1] |
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In Vivo |
N-desmethyl Enzalutamide is an active metabolite that is thought to contribute to the clinical effects of Enzalutamide because it demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as Enzalutamide. The carboxylic acid metabolite is pharmacologically inactive and circulates at approximately 25 % lower plasma concentrations than Enzalutamide[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molecular Weight |
450.41 |
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Formula |
C20H14F4N4O2S |
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CAS No. |
1242137-16-1 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
S=C(N1C2=CC(F)=C(C(N)=O)C=C2)N(C3=CC=C(C(C(F)(F)F)=C3)C#N)C(C(C)1C)=O |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 100 mg/mL (222.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.92% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.2202 mL | 11.1010 mL | 22.2020 mL | 55.5050 mL |
5 mM | 0.4440 mL | 2.2202 mL | 4.4404 mL | 11.1010 mL | |
10 mM | 0.2220 mL | 1.1101 mL | 2.2202 mL | 5.5505 mL | |
15 mM | 0.1480 mL | 0.7401 mL | 1.4801 mL | 3.7003 mL | |
20 mM | 0.1110 mL | 0.5550 mL | 1.1101 mL | 2.7752 mL | |
25 mM | 0.0888 mL | 0.4440 mL | 0.8881 mL | 2.2202 mL | |
30 mM | 0.0740 mL | 0.3700 mL | 0.7401 mL | 1.8502 mL | |
40 mM | 0.0555 mL | 0.2775 mL | 0.5550 mL | 1.3876 mL | |
50 mM | 0.0444 mL | 0.2220 mL | 0.4440 mL | 1.1101 mL | |
60 mM | 0.0370 mL | 0.1850 mL | 0.3700 mL | 0.9251 mL | |
80 mM | 0.0278 mL | 0.1388 mL | 0.2775 mL | 0.6938 mL | |
100 mM | 0.0222 mL | 0.1110 mL | 0.2220 mL | 0.5550 mL |
N-desmethyl Enzalutamide Related Classifications
- Vitamin D Related/Nuclear Receptor
- Androgen Receptor