Mycophenolic acid [24280-93-1]
Cat# HY-B0421-1ml
Size : 10mM/1mL
Brand : MedChemExpress
Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 µM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
For research use only. We do not sell to patients.
Mycophenolic acid Chemical Structure
CAS No. : 24280-93-1
This product is a controlled substance and not for sale in your territory.
Based on 7 publication(s) in Google Scholar
Other Forms of Mycophenolic acid:
- Mycophenolic acid sodium In-stock
- Mycophenolic acid-d3 In-stock
- Mycophenolic acid-13C17 Get quote
View All Antibiotic Isoform Specific Products:
Description |
Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 µM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects[1][2]. |
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IC50 & Target |
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In Vitro |
Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza, dengue virus, Zika virus, rotavirus, CCHFV, and hantavirus[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[2]
Western Blot Analysis[2]
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In Vivo |
Mycophenolic acid exerts its antitumor effects via modulation of the tumor microenvironment, U87 tumor growth is markedly inhibited in vivo in BALB/c nude mice[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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Molecular Weight |
320.34 |
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Formula |
C17H20O6 |
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CAS No. |
24280-93-1 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=C(O)CC/C(C)=C/CC1=C(O)C2=C(COC2=O)C(C)=C1OC |
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Structure Classification |
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Initial Source |
several species of Penicillium |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : ≥ 100 mg/mL (312.17 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : < 0.1 mg/mL (insoluble) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.87% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 3.1217 mL | 15.6084 mL | 31.2168 mL | 78.0421 mL |
5 mM | 0.6243 mL | 3.1217 mL | 6.2434 mL | 15.6084 mL | |
10 mM | 0.3122 mL | 1.5608 mL | 3.1217 mL | 7.8042 mL | |
15 mM | 0.2081 mL | 1.0406 mL | 2.0811 mL | 5.2028 mL | |
20 mM | 0.1561 mL | 0.7804 mL | 1.5608 mL | 3.9021 mL | |
25 mM | 0.1249 mL | 0.6243 mL | 1.2487 mL | 3.1217 mL | |
30 mM | 0.1041 mL | 0.5203 mL | 1.0406 mL | 2.6014 mL | |
40 mM | 0.0780 mL | 0.3902 mL | 0.7804 mL | 1.9511 mL | |
50 mM | 0.0624 mL | 0.3122 mL | 0.6243 mL | 1.5608 mL | |
60 mM | 0.0520 mL | 0.2601 mL | 0.5203 mL | 1.3007 mL | |
80 mM | 0.0390 mL | 0.1951 mL | 0.3902 mL | 0.9755 mL | |
100 mM | 0.0312 mL | 0.1561 mL | 0.3122 mL | 0.7804 mL |
Mycophenolic acid Related Classifications
- Inflammation/Immunology Infection Cancer
- Cancer Targeted Therapy Cancer Immunotherapy Cancer Drug Resistance Cancer Metabolism and Metastasis
- Apoptosis Anti-infection Metabolic Enzyme/Protease
- Dengue virus Apoptosis Bacterial Fungal Endogenous Metabolite Antibiotic Flavivirus