A549
|
IC50 |
1.6 nM
Compound: Mifepristone
|
Antagonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of corticoid-induced transcription after 16 hrs by glucocorticoid response element-driven luciferase reporter gene assay
Antagonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of corticoid-induced transcription after 16 hrs by glucocorticoid response element-driven luciferase reporter gene assay
|
[PMID: 19217285]
|
A549
|
IC50 |
1.6 nM
Compound: Mifepristone
|
Antagonist activity at human glucocorticoid receptor assessed as inhibition of corticoid-induced transcription in human A549 cells by GRE-linked luciferase reporter gene assay
Antagonist activity at human glucocorticoid receptor assessed as inhibition of corticoid-induced transcription in human A549 cells by GRE-linked luciferase reporter gene assay
|
[PMID: 17317167]
|
A549
|
IC50 |
6 nM
Compound: 1, mifepristone,RU-486
|
Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase reporter gene assay
Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase reporter gene assay
|
[PMID: 17855092]
|
CHO
|
IC50 |
|
Activity at GR expressed in CHO cells assessed as decrease in dexamethasone-stimulated alkaline phosphatase production by GRAF assay
Activity at GR expressed in CHO cells assessed as decrease in dexamethasone-stimulated alkaline phosphatase production by GRAF assay
|
[PMID: 16987661]
|
CHO-K1
|
IC50 |
|
Antagonist activity at human progesterone receptor expressed in CHO-K1 cells harboring firefly luciferase gene after 20 hrs by One-Glo luciferase reporter gene assay
Antagonist activity at human progesterone receptor expressed in CHO-K1 cells harboring firefly luciferase gene after 20 hrs by One-Glo luciferase reporter gene assay
|
[PMID: 31274313]
|
CHO-K1
|
IC50 |
|
Antagonist activity at human glucocorticoid receptor expressed in CHO-K1 cells harboring firefly luciferase gene after 20 hrs by One-Glo luciferase reporter gene assay
Antagonist activity at human glucocorticoid receptor expressed in CHO-K1 cells harboring firefly luciferase gene after 20 hrs by One-Glo luciferase reporter gene assay
|
[PMID: 31274313]
|
CHO-K1
|
IC50 |
|
Antagonist activity at human glucocorticoid receptor expressed in CHO-K1 cells assessed as inhibition of glucocorticoid receptor-dexamethasone coactivator protein-protein interaction incubated for 24 hrs by bioluminescence assay
Antagonist activity at human glucocorticoid receptor expressed in CHO-K1 cells assessed as inhibition of glucocorticoid receptor-dexamethasone coactivator protein-protein interaction incubated for 24 hrs by bioluminescence assay
|
[PMID: 31274313]
|
COS-7
|
IC50 |
0.6 nM
Compound: 1, mifepristone
|
Antagonist activity at cloned glucocorticoid receptor-ligand binding domain expressed in african green monkey COS7 cells by GAL4 luciferase reporter assay
Antagonist activity at cloned glucocorticoid receptor-ligand binding domain expressed in african green monkey COS7 cells by GAL4 luciferase reporter assay
|
[PMID: 18504132]
|
COS-7
|
IC50 |
0.6 nM
Compound: 3, mifepristone
|
Antagonist activity at human GR ligand binding domain expressed in african green monkey COS7 cells in presence of Dexamethasone by Gal4 hybrid assay
Antagonist activity at human GR ligand binding domain expressed in african green monkey COS7 cells in presence of Dexamethasone by Gal4 hybrid assay
|
[PMID: 18318463]
|
COS-7
|
IC50 |
3.2 nM
Compound: Mifepristone
|
Antagonist activity at glucocorticoid receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luciferase reporter gene assay
Antagonist activity at glucocorticoid receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luciferase reporter gene assay
|
[PMID: 19863083]
|
COS-7
|
IC50 |
5000 nM
Compound: 1, mifepristone
|
Antagonist activity at cloned estrogen receptor-ligand binding domain expressed in african green monkey COS7 cells by GAL4 luciferase reporter assay
Antagonist activity at cloned estrogen receptor-ligand binding domain expressed in african green monkey COS7 cells by GAL4 luciferase reporter assay
|
[PMID: 18504132]
|
COS-7
|
IC50 |
590 nM
Compound: 1, mifepristone
|
Antagonist activity at cloned mineralocorticoid receptor-ligand binding domain expressed in african green monkey COS7 cells by GAL4 luciferase reporter assay
Antagonist activity at cloned mineralocorticoid receptor-ligand binding domain expressed in african green monkey COS7 cells by GAL4 luciferase reporter assay
|
[PMID: 18504132]
|
COS-7
|
IC50 |
6.9 nM
Compound: 1, mifepristone
|
Antagonist activity at cloned androgen receptor-ligand binding domain expressed in african green monkey COS7 cells by two hybrid luciferase assay
Antagonist activity at cloned androgen receptor-ligand binding domain expressed in african green monkey COS7 cells by two hybrid luciferase assay
|
[PMID: 18504132]
|
COS-7
|
IC50 |
6.9 nM
Compound: 3, mifepristone
|
Antagonist activity at human AR ligand binding domain expressed in african green monkey COS7 cells in presence of 5-alpha-dihydrotestosterone by Gal4 hybrid assay
Antagonist activity at human AR ligand binding domain expressed in african green monkey COS7 cells in presence of 5-alpha-dihydrotestosterone by Gal4 hybrid assay
|
[PMID: 18318463]
|
CV-1
|
IC50 |
> 1000 nM
Compound: RU-486
|
Antagonist activity at human ERalpha expressed in african green monkey CV1 cells co-transfected with ERE-MMTV-Luc by luciferase reporter gene assay
Antagonist activity at human ERalpha expressed in african green monkey CV1 cells co-transfected with ERE-MMTV-Luc by luciferase reporter gene assay
|
[PMID: 20510622]
|
CV-1
|
EC50 |
> 10000 nM
Compound: RU-486
|
Agonist activity at human progesterone receptor B expressed in african green monkey CV1 cells co-transfected with MMTV-Luc after 24 hrs by luciferase reporter gene assay
Agonist activity at human progesterone receptor B expressed in african green monkey CV1 cells co-transfected with MMTV-Luc after 24 hrs by luciferase reporter gene assay
|
[PMID: 20510622]
|
CV-1
|
EC50 |
> 10000 nM
Compound: RU-486
|
Agonist activity at human ERalpha expressed in african green monkey CV1 cells co-transfected with ERE-MMTV-Luc after 24 hrs by luciferase reporter gene assay
Agonist activity at human ERalpha expressed in african green monkey CV1 cells co-transfected with ERE-MMTV-Luc after 24 hrs by luciferase reporter gene assay
|
[PMID: 20510622]
|
CV-1
|
EC50 |
> 10000 nM
Compound: RU-486
|
Agonist activity at human ERbeta expressed in african green monkey CV1 cells co-transfected with ERE-MMTV-Luc after 24 hrs by luciferase reporter gene assay
Agonist activity at human ERbeta expressed in african green monkey CV1 cells co-transfected with ERE-MMTV-Luc after 24 hrs by luciferase reporter gene assay
|
[PMID: 20510622]
|
CV-1
|
EC50 |
> 10000 nM
Compound: RU-486
|
Agonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc after 24 hrs by luciferase reporter gene assay
Agonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc after 24 hrs by luciferase reporter gene assay
|
[PMID: 20510622]
|
CV-1
|
IC50 |
> 10000 nM
Compound: RU-486
|
Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc by luciferase reporter gene assay
Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc by luciferase reporter gene assay
|
[PMID: 20510622]
|
CV-1
|
IC50 |
0.3 nM
Compound: Mifepristone
|
Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells
Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells
|
[PMID: 12781197]
|
CV-1
|
IC50 |
|
Antagonist activity against progesterone receptor (PR) using PRE-luciferase plasmid co-transfected CV-1 cells
Antagonist activity against progesterone receptor (PR) using PRE-luciferase plasmid co-transfected CV-1 cells
|
[PMID: 12238914]
|
CV-1
|
IC50 |
|
Antagonist activity at human progesterone receptor B expressed in african green monkey CV1 cells co-transfected with MMTV-Luc assessed as effect on progesterone-induced activity by luciferase reporter gene assay
Antagonist activity at human progesterone receptor B expressed in african green monkey CV1 cells co-transfected with MMTV-Luc assessed as effect on progesterone-induced activity by luciferase reporter gene assay
|
[PMID: 20510622]
|
CV-1
|
EC50 |
0.6 nM
Compound: mifepristone
|
Antagonist activity at human GR expressed in CV1 cells by GRE activation assay
Antagonist activity at human GR expressed in CV1 cells by GRE activation assay
|
[PMID: 17705362]
|
CV-1
|
IC50 |
|
Antagonist activity at human glucocorticoid receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc by luciferase reporter gene assay
Antagonist activity at human glucocorticoid receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc by luciferase reporter gene assay
|
[PMID: 20510622]
|
CV-1
|
IC50 |
|
Antagonist activity at human androgen receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc by luciferase reporter gene assay
Antagonist activity at human androgen receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc by luciferase reporter gene assay
|
[PMID: 20510622]
|
CV-1
|
EC50 |
|
Agonist activity at human androgen receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc after 24 hrs by luciferase reporter gene assay
Agonist activity at human androgen receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc after 24 hrs by luciferase reporter gene assay
|
[PMID: 20510622]
|
CV-1
|
IC50 |
|
Antagonist activity at human ERbeta expressed in african green monkey CV1 cells co-transfected with ERE-MMTV-Luc by luciferase reporter gene assay
Antagonist activity at human ERbeta expressed in african green monkey CV1 cells co-transfected with ERE-MMTV-Luc by luciferase reporter gene assay
|
[PMID: 20510622]
|
CV-1
|
EC50 |
|
Agonist activity at human glucocorticoid receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc after 24 hrs by luciferase reporter gene assay
Agonist activity at human glucocorticoid receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc after 24 hrs by luciferase reporter gene assay
|
[PMID: 20510622]
|
HCC1937
|
IC50 |
|
Antiproliferative activity against human HCC1937 cells after 48 hrs by SRB assay
Antiproliferative activity against human HCC1937 cells after 48 hrs by SRB assay
|
[PMID: 29407962]
|
HEK293
|
IC50 |
|
Antagonist activity against glucocorticoid receptor (unknown origin) expressed in HEK293 cells by GRE-dependent luciferase reporter gene assay
Antagonist activity against glucocorticoid receptor (unknown origin) expressed in HEK293 cells by GRE-dependent luciferase reporter gene assay
|
[PMID: 26218343]
|
K562/R7
|
IC50 |
|
Potentiation of doxorubicin-induced cytotoxicity against doxorubicin-resistant human K562/R7 cells assessed as doxorubicin IC50 at 1 uM after 72 hrs by MTT assay
Potentiation of doxorubicin-induced cytotoxicity against doxorubicin-resistant human K562/R7 cells assessed as doxorubicin IC50 at 1 uM after 72 hrs by MTT assay
|
[PMID: 25634041]
|
LNCaP
|
EC50 |
|
Agonist activity at human androgen receptor in human LNCAP cells harboring firefly luciferase gene after 20 hrs by One-Glo luciferase reporter gene assay
Agonist activity at human androgen receptor in human LNCAP cells harboring firefly luciferase gene after 20 hrs by One-Glo luciferase reporter gene assay
|
[PMID: 31274313]
|
MCF7
|
IC50 |
24.03 μM
Compound: Mifepristone
|
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by CCK-8 assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by CCK-8 assay
|
[PMID: 33461148]
|
SUM149PT
|
IC50 |
|
Antiproliferative activity against human SUM149PT cells after 48 hrs by SRB assay
Antiproliferative activity against human SUM149PT cells after 48 hrs by SRB assay
|
[PMID: 29407962]
|
T47D
|
IC50 |
0.045 nM
Compound: 1, RU-486
|
Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 48 hrs
Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 48 hrs
|
[PMID: 19216549]
|
T47D
|
IC50 |
0.6 nM
Compound: 3, mifepristone
|
Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay
Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assay
|
[PMID: 18318463]
|