Metapneumovirus, Matrix Protein (hMPV)

Human Metapneumovirus (HMPV) is an enveloped, negative single-stranded RNA virus belonging to the genus Metapneumovirus, of the family Pneumoviridae. HPMV is closely related to Respiratory Syncytial virus (RSV), which belongs to the genus Orthopneumovirus within the same family (Alfonso, CL). Human Metapneumovirus is globally widespread and seasonal in temperate climates, being most active from winter to spring. Genomic analysis has shown that HMPV exists as two genotypes A and B, which are further divided into subgroups A1, A2 and B1, B2. Each of these subgroups has a distinct geographical distribution but may circulate separately or concurrently (Boivin, G). Transmission of HPMV from person-to-person predominantly occurs through contact with airborne droplets from an infected individual, produced by coughing or sneezing. It can also be spread through contact with contaminated hands or surfaces.|Identified in 2001, HPMV, is one of the most common causes of pediatric lower respiratory tract infection. However, the virus can affect individuals of all ages infecting the upper or lower respiratory tract. The symptoms of HPMV infection include coughing, fever, wheezing and shortness of breath but in some cases bronchitis or pneumonia can develop. HMPV can cause severe life-threatening illness in pediatric, geriatric and immunocompromised patients (CDC).||Applications: |Suitable for use in ELISA, Immunofluorescence and Lateral Flow. Other applications not tested.||Recommended Dilution:|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.