Laforin (EPM2, Epilepsy Progressive Myoclonus Type 2 Lafora Disease (Laforin), Epilepsy Progressive Myoclonus Type 2A Lafora Disease (Laforin), EPM2, Epm2a, Lafora PTPase, LAFPTPase, LD, LDE, MELF)
Cat# 384918-100ug
Size : 100ug
Brand : US Biological
384918 Rabbit Anti-Laforin (EPM2, Epilepsy Progressive Myoclonus Type 2 Lafora Disease (Laforin), Epilepsy Progressive Myoclonus Type 2A Lafora Disease (Laforin), EPM2, Epm2a, Lafora PTPase, LAFPTPase, LD, LDE, MELF)
Clone Type
PolyclonalHost
mouseSource
humanSwiss Prot
O95278Isotype
IgG1Grade
Affinity PurifiedApplications
IC IF WBCrossreactivity
HuAccession #
NP_001018051.1Shipping Temp
Blue IceStorage Temp
-20°CLaforin, also known as Lafora PTPase, is a dual specificity protein phosphatase. Laforin is involved in the control of glycogen metabolism, specifically in preventing the formation of poorly branched glycogen molecules (polyglucosans). Laforin forms a complex with NHLRC1/malin and HSP70 that suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Laforin is expressed in heart, skeletal muscle, kidney, pancreas and brain. Defective Laforin is linked to progressive myoclonic epilepsy type 2 (EPM2).||Applications: |Suitable for use in Western Blot, Immunocytochemistry/Immunofluorescence. Other applications not tested.||Recommended Dilution:|Western Blot: 1:1000|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.