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> L-DABA [1758-80-1]

L-DABA [1758-80-1]

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Cat# T7595-50mg

Size : 50mg

Brand : TargetMol


L-DABA

L-DABA
L-DABA (L-2,4-Diaminobutyric acid) is an inhibitor of GABA transaminase with an IC50 greater than 500 μM.
Catalog No. T7595Cas No. 1758-80-1
Purity:98%
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L-DABA

Catalog No. T7595Cas No. 1758-80-1
L-DABA (L-2,4-Diaminobutyric acid) is an inhibitor of GABA transaminase with an IC50 greater than 500 μM.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack Size
25 mgIn Stock

Product Introduction

Bioactivity
Description
L-DABA (L-2,4-Diaminobutyric acid) is an inhibitor of GABA transaminase with an IC50 greater than 500 μM.
In vitro
L-2,4-Diaminobutyric acid(DABA) was a non-linear, non-competitive inhibitor of GABA transaminase activity. The DABA-induced elevation of GABA levels paralleled the inhibition of GABA transaminase activity. DABA was a more effective inhibitor of GABA transaminase in vivo than in vitro, and this inhibition probably produced the elevation of GABA levels. The neurotoxicity of DABA appears to produce a use in GABA replacement therapy[1].
AliasL-2,4-Diaminobutyric acid, L-DAB HBR
Chemical Properties
Molecular Weight118.13
FormulaC4H10N2O2
Cas No.1758-80-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: Insoluble
H2O: Insoluble

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Gamma-aminobutyric acid ReceptorInhibitorinhibitLDABAGABA ReceptorL DABAEndogenous Metaboliteγ-Aminobutyric acid ReceptorL-DABA
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