Il3 rat monoclonal antibody, clone MP2-8F8, Low Endotoxin
Specifications
Product Data
Clone Name
MP2-8F8
Application
FC, IF, Neutralize
Recommended Dilution
Immunofluorescence/Flow Cytometry: This antibody is useful for intracytoplasmic staining and flow cytometric analysis to identify and enumerate IL-3-positive cells within mixed cell populations. Recombinant mouse IL-3 (Cat#AM08179PU-N) should be used as a Specificity Control. Neutralization: This Low Endotoxin/Azide free Antibody can be used for Neutralizing mouse IL-3 bioactivity.
Reactivity
Mouse
Antibody Host
Rat
Isotype
IgG1
Clonality
Monoclonal
Immunogen
COS-expressed recombinant mouse IL-3.
Specificity
This antibody is specific to Mouse Interleukin-3/IL-3. (Ref.1-3) (This is a Neutralizing antibody).
The pleiotropic IL3 (Interleukin 3) is a 15kDa cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL3 acts in hematopoiesis by controlling the production, differentiation, and function of two related white cell populations of the blood, the granulocytes and the monocytes/macrophages. It induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes and is expressed by activated T cells, mast cells, and natural killer cells. IL3 not only supports growth of both pluripotent stem cells and the more differentiated committed progenitors, but it also stimulates the functional activity of some fully differentiated cells. IL3 has also been shown to protect mast cells from undergoing apoptosis.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
