IL-36 gamma, Recombinant, Mouse (Interleukin gamma, Interleukin-1 Family Member 9, IL-1F9)

Cat# 044938-10ug

Size : 10ug

Brand : US Biological

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044938 IL-36 gamma, Recombinant, Mouse (Interleukin gamma, Interleukin-1 Family Member 9, IL-1F9)

Clone Type
Polyclonal
Swiss Prot
Q8R460
Grade
Highly Purified
Shipping Temp
Blue Ice
Storage Temp
-20°C

IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.||Biological Activity:|Induces secretion of IL-6 in BMDCs.||Sequence:|IL-36gamma (mouse) (aa 13-164) is untagged. ||Storage and Stability:|Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Applications
Source: E. coli|Purity: ~95% (SDS-PAGE). Endotoxin: ≤0.01EU/ug (LAL)|Concentration: ~0.1mg/ml (after reconstitution)|Form: Supplied as a lyophilized powder from PBS, 0.5% trehalose. Reconstitute with 100ul sterile ddH2O.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Form
Supplied as a lyophilized powder from PBS, 0.5% trehalose. Reconstitute with 100ul sterile ddH2O.
Purity
~95% (SDS-PAGE). Endotoxin: ≤0.01EU/ug (LAL)