Human Thyroid Peroxidase (TPO) IgG ELISA kit
Cat# EA100926
Size : 1x96wells
Human Thyroid Peroxidase (TPO) IgG ELISA kit
SKU
EA100926
Human Thyroid Peroxidase (TPO) IgG ELISA kit
2 Weeks*
| Product Data | |
| ACCN | NM_000547.5 |
|---|---|
| Assay Length | 3 hours |
| Assay Platform | 96-well plate |
| Assay Type | Solid Phase Sandwich ELISA |
| Assay Type | Sandwich |
| Background | Thyroid peroxidase (TPO) is the major autoantigen (933 amino acid residue) in the thyroid microsomal antigen (TMA) particle. The purification and preparation of this antigen has made testing for TMA antibodies obsolete. Assays for TPO antibodies include ELISA, precipitation of radiolabeled TPO-bound autoantibodies with protein A, competition for TPO binding to immobilized anti-TPO murine monoclonal antibodies, autoantibody capture by TPO-coated beads and chemiluminescence. All tests correlate well with detection of TMA. ELISA using TPO recombinant antigen is the most popular assay. Detection of TPO antibodies is strong evidence against a goiter or non-autoimmune causes of hypothyroidism. The annual risk for the development of hypothyroidism is 3% to 4% per year if TPO antibodies are present and TSH is elevated. TPO antibodies are present in 8-9% normal controls, 57-74% patients with Graves disease, 99- 100% of Hashimoto disease or idiopathic myxedema, 19% with differentiated thyroid cancer, no patients with subacute thyroiditis and 11% of those with other miscellaneous non-autoimmune thyroid diseases. The prevalence of positive TPO antibodies is higher in elderly (mean age 80 years) women (10%) compared to elderly men (2%). Autoantibody concentration in centenarians also decreases. Studies of TPO epitopes in each domain, A and B, and detection of their specific autoantibodies suggest that the epitope-specific TPO antibodies ratio (A/B) does not change over time in individual patients and that TPO epitope autoantibody patterns may be inherited. |
| Components |
|
| Cross Reactivity | There is no detectable cross-reactivity with other relevant proteins. |
| Format | 8x12 divisible strips |
| Gene Symbol | TNNI3 |
| Interference | No significant interference observed with available related molecules. |
| Locus ID | 7137 |
| Reactivity | Human |
| Reactivity | Human |
| Reactivity | Human |
| Sample Type | Serum |
| Sample Volume | 10 µl/well |
| Signal | Colorimetric |
| Species | Human |
| Specificity | This kit is used for quantitative detection human Thyroid Peroxidase (TPO) IgG |
| Target Symbol | TNNI3 |
| Description | Human Thyroid Peroxidase (TPO) IgG ELISA kit |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.