Human Alpha-Synuclein Protein
Cat# orb640151-200ug
Size : 200ug
Brand : Biorbyt
Human Alpha-Synuclein Protein
Catalog Number: orb640151
Catalog Number | orb640151 |
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Category | Proteins |
Description | Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DJC5. This chaperone activity is important to sustain normal SRE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity. |
Reactivity | Human |
Tag | C-10×His |
Form/Appearance | Powder |
Purity | 90% |
Conjugation | Unconjugated |
MW | 16.3 kDa |
Target | Alpha-Synuclein |
UniProt ID | P37840 |
Protein Sequence | NP_000336.1 |
Source | Human Alpha-Synuclein, His Tag (orb640151) is expressed from E. coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1). |
Expression System | E. coli |
Biological Origin | Human |
Expression Region | Met 1 - Ala 140 |
Endotoxins | 1.0 EU per μg |
NCBI | NP_000336.1 |
Storage | -20°C |
Buffer/Preservatives | 100 mM NaAC, pH7.0 |
Alternative names | SNCA,NACP,PARK1,alpha-Synuclein |
Note | For research use only |
Application notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.3 kDa. The protein migrates as 19 kDa under reducing (R) condition (SDS-PAGE). |
Expiration Date | 6 months from date of receipt. |