Cotrimoxazole (Trimethoprim/sulfamethoxazole 1:5) [8064-90-2]
Cat# HY-141619-250mg
Size : 250mg
Brand : MedChemExpress
Cotrimoxazole (Trimethoprim/sulfamethoxazole 1:5) is an active compound for toxoplasmic encephalitis inhibition, as well as inhibition in protozoan and bacterial infections.
For research use only. We do not sell to patients.
Cotrimoxazole (Trimethoprim/sulfamethoxazole 1:5) Chemical Structure
CAS No. : 8064-90-2
Based on 1 publication(s) in Google Scholar
Other Forms of Cotrimoxazole (Trimethoprim/sulfamethoxazole 1:5):
- Cotrimoxazole (Trimethoprim/sulfamethoxazole 1:19) In-stock
View All Parasite Isoform Specific Products:
Description |
Cotrimoxazole (Trimethoprim/sulfamethoxazole 1:5) is an active compound for toxoplasmic encephalitis inhibition, as well as inhibition in protozoan and bacterial infections[1][2]. |
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Molecular Weight |
543.60 |
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Formula |
C24H29N7O6S |
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CAS No. |
8064-90-2 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=S(NC1=NOC(C)=C1)(C2=CC=C(C=C2)N)=O.NC3=NC=C(CC4=CC(OC)=C(C(OC)=C4)OC)C(N)=N3 |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 100 mg/mL (183.96 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.79% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 1.8396 mL | 9.1979 mL | 18.3959 mL | 45.9897 mL |
5 mM | 0.3679 mL | 1.8396 mL | 3.6792 mL | 9.1979 mL | |
10 mM | 0.1840 mL | 0.9198 mL | 1.8396 mL | 4.5990 mL | |
15 mM | 0.1226 mL | 0.6132 mL | 1.2264 mL | 3.0660 mL | |
20 mM | 0.0920 mL | 0.4599 mL | 0.9198 mL | 2.2995 mL | |
25 mM | 0.0736 mL | 0.3679 mL | 0.7358 mL | 1.8396 mL | |
30 mM | 0.0613 mL | 0.3066 mL | 0.6132 mL | 1.5330 mL | |
40 mM | 0.0460 mL | 0.2299 mL | 0.4599 mL | 1.1497 mL | |
50 mM | 0.0368 mL | 0.1840 mL | 0.3679 mL | 0.9198 mL | |
60 mM | 0.0307 mL | 0.1533 mL | 0.3066 mL | 0.7665 mL | |
80 mM | 0.0230 mL | 0.1150 mL | 0.2299 mL | 0.5749 mL | |
100 mM | 0.0184 mL | 0.0920 mL | 0.1840 mL | 0.4599 mL |
Cotrimoxazole (Trimethoprim/sulfamethoxazole 1:5) Related Classifications
- Anti-infection
- Parasite Bacterial