CNQX disodium salt [479347-85-8]
Cat# B6567-10mg
Size : 10mg
Brand : APExBIO Technology
CNQX disodium salt
CNQX disodium salt is an antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate receptors, with IC50 values of 0.3 and 1.5 μM, respectively [1].]. μM) depolarized all cells tested in a similar manner as DNQX. With longer CNQX application (5 min vs. 1 min), the depolarization persisted throughout CNQX application. However, in ventrobasal neurons, CNQX (20 μM) produced negligible effects on the membrane potential [3]., 0.1, 0.6, 3 and 15%. The number of c-fos-like immunoreactivity cells within lateral reticular, medullary reticular, and solitary tract nuclei was not affected [4].]. Honoré T, Davies S N, Drejer J, et al. Quinoxalinediones: Potent competitive non-NMDA glutamate receptor antagonists. Science, 1988, 241(4866): 701-703.
[2]. Bettler B, Mulle C. AMPA and kainate receptors. Neuropharmacology, 1995, 34(2): 123-139.
[3]. Lee S H, Govindaiah G, Cox C L. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. Journal of Neurophysiology, 2010, 103(4): 1728-1734.
[4]. Mitsikostas D D, Sanchez del Rio M, Waeber C, et al. Non-NMDA glutamate receptors modulate capsaicin induced c-fos expression within trigeminal nucleus caudalis. British Journal of Pharmacology, 1999, 127(3): 623-630.
| Physical Appearance | A solid |
| Storage | Desiccate at RT |
| M.Wt | 276.12 |
| Cas No. | 479347-85-8 |
| Formula | C9H2N4O4Na2 |
| Solubility | mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| Chemical Name | sodium 6-cyano-7-nitroquinoxaline-2,3-bis(olate) |
| SDF | Download SDF |
| Canonical SMILES | [O-]C(N=C(C=C1[N+]([O-])=O)C(C=C1C#N)=N2)=C2[O-].[Na+].[Na+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |