CD81 monoclonal antibody, clone M38 (FITC)
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Flow Cytometry
Flow cytometric surface staining of human peripheral blood stained with CD81 monoclonal antibody, clone M38 (FITC) (Cat # MAB6494).
- Specifications
Product Description
Mouse monoclonal antibody raised against native CD81.
Immunogen
Native purified CD81 from human T-ALL cell line (MOLT-4).
Host
Mouse
Theoretical MW (kDa)
25
Reactivity
Cat, Human, Rabbit
Specificity
This antibody reacts with CD81, a 25 KDa member of the tetraspanin family, expressedon majority of cells.
Form
Liquid
Conjugation
FITC
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
Flow Cytometry
Flow cytometric surface staining of human peripheral blood stained with CD81 monoclonal antibody, clone M38 (FITC) (Cat # MAB6494). - Gene Info — CD81
Entrez GeneID
975Gene Name
CD81
Gene Alias
S5.7, TAPA1, TSPAN28
Gene Description
CD81 molecule
Omim ID
186845Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. [provided by RefSeq
Other Designations
26 kDa cell surface protein TAPA-1|CD81 antigen|CD81 antigen (target of antiproliferative antibody 1)|target of antiproliferative antibody 1
- Interactomes
- Pathways
- Diseases
- Publication Reference
- Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes.
Escola JM, Kleijmeer MJ, Stoorvogel W, Griffith JM, Yoshie O, Geuze HJ.
The Journal of Biological Chemistry 1998 Aug; 273(32):20121.
- Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82.
T Imai, M Kakizaki, M Nishimura, O Yoshie.
Journal of Immunology 1995 Aug; 155(3):1229.
- C33 antigen and M38 antigen recognized by monoclonal antibodies inhibitory to syncytium formation by human T cell leukemia virus type 1 are both members of the transmembrane 4 superfamily and associate with each other and with CD4 or CD8 in T cells.
Imai T, Yoshie O.
The Journal of Immunology 1993 Dec; 151(11):6470.
- Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes.