Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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100 mg
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Camptothecin (7689-03-4) is a natural product isolated from the Chinese Happy Tree, Camptotheca acuminate. It is an inhibitor of DNA topoisomerase I. Camptothecin binds irreversibly to the topoisomerase I /DNA complex preventing DNA re-ligation and generating permanent double strand breaks. Potent antitumor agent.
References/Citations:
1) Hsiang et al. (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.; J. Biol. Chem., 260 14873 2) Li et al. (2006) Review camptothecin: current perspectives; Curr. Med. Chem., 13 2021
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee
Camptothecin (7689-03-4) is a natural product isolated from the Chinese Happy Tree, Camptotheca acuminate. It is an inhibitor of DNA topoisomerase I. Camptothecin binds irreversibly to the topoisomerase I /DNA complex preventing DNA re-ligation and generating permanent double strand breaks. Potent antitumor agent.
References/Citations:
1) Hsiang et al. (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.; J. Biol. Chem., 260 14873 2) Li et al. (2006) Review camptothecin: current perspectives; Curr. Med. Chem., 13 2021
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