Calpeptin [117591-20-5]
Cat# HY-100223-5mg
Size : 5mg
Brand : MedChemExpress
Calpeptine est un inhibiteur puissant de la calpaïne pénétrant dans les cellules, avec un ID50 de 40 nM pour la Calpain I dans les plaquettes humaines. Calpeptine est également un inhibiteur de la cathepsine K.
Calpeptin ist ein starker, zelldurchdringender calpain-Inhibitor mit einer ID50 von 40 nM für Calpain I in menschlichen Blutplättchen. Calpeptin ist auch ein Inhibitor von cathepsin K.
Calpeptin is a potent, cell penetrating calpain inhibitor, with an ID50 of 40 nM for Calpain I in human platelets. Calpeptin is also an inhibitor of cathepsin K.
For research use only. We do not sell to patients.
Calpeptin Chemical Structure
CAS No. : 117591-20-5
This product is a controlled substance and not for sale in your territory.
Based on 21 publication(s) in Google Scholar
View All Cathepsin Isoform Specific Products:
Description |
Calpeptin is a potent, cell penetrating calpain inhibitor, with an ID50 of 40 nM for Calpain I in human platelets[1]. Calpeptin is also an inhibitor of cathepsin K[2]. |
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IC50 & Target |
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In Vitro |
Calpeptin (0-100 nM, 24 hours) treatment suppresses the proliferation of both WI38 VA13 and IMR90 cells in a dose-dependent manner. Calpeptin (1000 pg/ml, 24 hours) inhibits IL-6-induced cell proliferation of lung fibroblasts[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[3]
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In Vivo |
Calpeptin with Bleo (0.04 mg/mouse, i.p., 3 times weekly, 28 days) administration significantly inhibits the collagen deposition and increases of calpain activity in the NSC-125066 treated mouse lung tissues[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Molecular Weight |
362.46 |
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Formula |
C20H30N2O4 |
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CAS No. |
117591-20-5 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=C(OCC1=CC=CC=C1)N[C@H](C(N[C@H](C=O)CCCC)=O)CC(C)C |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 100 mg/mL (275.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: ≥98.0% COA (245 KB) HNMR (137 KB) Handling Instructions (2659 KB) |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.7589 mL | 13.7946 mL | 27.5893 mL | 68.9731 mL |
5 mM | 0.5518 mL | 2.7589 mL | 5.5179 mL | 13.7946 mL | |
10 mM | 0.2759 mL | 1.3795 mL | 2.7589 mL | 6.8973 mL | |
15 mM | 0.1839 mL | 0.9196 mL | 1.8393 mL | 4.5982 mL | |
20 mM | 0.1379 mL | 0.6897 mL | 1.3795 mL | 3.4487 mL | |
25 mM | 0.1104 mL | 0.5518 mL | 1.1036 mL | 2.7589 mL | |
30 mM | 0.0920 mL | 0.4598 mL | 0.9196 mL | 2.2991 mL | |
40 mM | 0.0690 mL | 0.3449 mL | 0.6897 mL | 1.7243 mL | |
50 mM | 0.0552 mL | 0.2759 mL | 0.5518 mL | 1.3795 mL | |
60 mM | 0.0460 mL | 0.2299 mL | 0.4598 mL | 1.1496 mL | |
80 mM | 0.0345 mL | 0.1724 mL | 0.3449 mL | 0.8622 mL | |
100 mM | 0.0276 mL | 0.1379 mL | 0.2759 mL | 0.6897 mL |
Calpeptin Related Classifications
- Metabolic Enzyme/Protease Apoptosis
- Cathepsin Proteasome Apoptosis