- More Files
- Specifications
Product Description
C5 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human C5.
Suitable Sample
Cell Culture Samples, CSF, Milk, Plasma, Saliva and Serum
Sample Volume
50 uL
Label
Peroxidase-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
0.156 to 10 ng/mL
Reactivity
Human, Monkey
Regulation Status
For research use only (RUO)
Storage Instruction
Store components of the kit at 4°C or -20°C as described in the protocol.
- Applications
Quantification
- Gene Info — C5
Entrez GeneID
727Gene Name
C5
Gene Alias
CPAMD4, FLJ17816, FLJ17822, MGC142298
Gene Description
complement component 5
Omim ID
120900Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq
Other Designations
OTTHUMP00000022001|anaphylatoxin C5a analog
- Interactomes
- Pathways
- Diseases
- Publication Reference
- Development of the Complement C5 Assay by LC-MS/MS in Monkey Serum and Comparison with Enzyme-Linked Immunosorbent Assay.
Kiyomi Kikuchi, Yoko Ida, Tomohiro Yamada, Yuji Mano.
American Chemical Society omega 2024 Jan; 9(6):6797.
Application:ELISA, Monkey, Blood samples.
- Identification of potent siRNA targeting complement C5 and its robust activity in pre-clinical models of myasthenia gravis and collagen-induced arthritis.
Yoshikazu Kuboi, Yuta Suzuki, Sotaro Motoi, Chiyuki Matsui, Naoki Toritsuka, Tomoya Nakatani, Kazuhiro Tahara, Yoshinori Takahashi, Yoko Ida, Ayaka Tomimatsu, Motohiro Soejima, Toshio Imai.
Molecular Therapy. Nucleic Acids 2023 Mar; 31:339.
Application:Quant, Monkey, Monkey serum.
- C5a/C5aR pathway is essential for the pathogenesis of murine viral fulminant hepatitis via potentiating Fgl2/fibroleukin expression.
Xu GL, Chen J, Yang F, Li GQ, Zheng LX, Wu YZ.
Hepatology 2014 Jul; 60(1):114.
Application:ELISA, Human, Serum.
- Development of the Complement C5 Assay by LC-MS/MS in Monkey Serum and Comparison with Enzyme-Linked Immunosorbent Assay.