Bone Marrow CD34+ Stem/Progenitor Cells, Frozen
Bone Marrow CD34+ Stem/Progenitor Cells, Frozen
CD34 is a glycosylated transmembrane protein and represents a well-established marker for human hematopoietic stem and progenitor cells in peripheral blood, bone marrow, and cord blood. CD34+ cells are self-renewing, multipotent stem cells that give rise to all blood cells of the immune system through a process called hematopoiesis. As hematopoietic stem cells progress through hematopoiesis they generate the myeloid (monocytes, macrophages, granulocytes, megakaryocytes, dendritic cells, erythrocytes) and lymphoid (T cells, B cells, NK cells) lineages. The highly specialized cells that arise from hematopoietic stem cells work collaboratively in defending the body against infection and disease.
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CGT Global is a Biospecimen Provider for a wide range of clinical and preclinical research projects. Our state-of-the-art laboratories and collection centers are located nationwide and provide end-to-end services: These services include: ":0,"335559739":0,"335559740":240}">":0,"335559685":0,"335559731":0,"335559739":0,"335559740":240}">":0,"335559685":0,"335559731":0,"335559739":0,"335559740":240}">":0,"335559685":0,"335559731":0,"335559739":0,"335559740":240}">pme2x7h39 fl-col-small" data-node="sj5pme2x7h39"> 
Description
CD34 is a glycosylated transmembrane protein and represents a well-established marker for human hematopoietic stem and progenitor cells in peripheral blood, bone marrow, and cord blood. CD34+ cells are self-renewing, multipotent stem cells that give rise to all blood cells of the immune system through a process called hematopoiesis. As hematopoietic stem cells progress through hematopoiesis they generate the myeloid (monocytes, macrophages, granulocytes, megakaryocytes, dendritic cells, erythrocytes) and lymphoid (T cells, B cells, NK cells) lineages. The highly specialized cells that arise from hematopoietic stem cells work collaboratively in defending the body against infection and disease.
Bone marrow mononuclear cells (MNCs) are separated from whole bone marrow by a density gradient centrifugation protocol. CD34+ cells are positively selected using immunomagnetic anti-CD34 (clone QBEND10) microbeads from bone marrow mononuclear cells. Isolated primary cells are characterized by flow cytometry before cryopreservation to ensure a highly pure and viable cell population.
Cells were obtained using Institutional Review Board (IRB) approved consent forms and protocols.
Additional information
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Product Information Sheet
Certificate of Analysis
Material Safety Data Sheet
Protocols
Publications
- Eksioglu et al. (2017) Antibody BI 836858. Leukemia 1-9. doi:10.1038/leu.2017.21. Abstract
- Hudak et al. (2014): 69-75. doi:10.1038/nchembio.1388. Abstract
- Modarai et al. (2018)+ Cells Directed by a Ribonucleoprotein Complex. Mol Ther Nucl Acids 11: 116-129. doi.org/10.1016/j.omtn.2018.01.013. Article
- Cheng et al. (2019)A9-Induced Overexpression of PD-1/PD-L1 Contributes to Ineffective Hematopoiesis in Myelodysplastic Syndromes. Leukemia. doi.org/10.1038/s41375-019-0397-9. Article
- Lo et al. (2020)ʹ-Chloromethyl-2ʹ-Deoxy-2ʹ-Fluorocytidine Against Nipah Virus.16/j.antiviral.2020.104712. Abstract
- Modarai et al. (2020)+ Cells Varies Widely Among Patient Samples.38/s41434-020-00192-z. Article
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