BMS-986313 is a potent, selective, orally active RORγt inverse agonist with EC50 of 3.6 nM in GAL-4 reporter assay in Jurkat cell line, and 50 nM in IL-17 human whole blood assay.BMS-986313 demonstrated robust efficacy in preclinical models of psoriasis (the IMQ-induced skin lesion model and the IL-23-induced acanthosis model).
Cat# orb1910405-100mg
Size : 100mg
Brand : Biorbyt
BMS-986313
Catalog Number: orb1910405
| Catalog Number | orb1910405 |
|---|---|
| Category | Small Molecules |
| Description | BMS-986313 is a potent, selective, orally active RORγt inverse agonist with EC50 of 3.6 nM in GAL-4 reporter assay in Jurkat cell line, and 50 nM in IL-17 human whole blood assay.BMS-986313 demonstrated robust efficacy in preclinical models of psoriasis (the IMQ-induced skin lesion model and the IL-23-induced acanthosis model). |
| MW | 498.92 |
| SMILES | O=C1C(C2=NN=C(CC3=NC=C(Cl)C=C3)O2)=C(O)C(C4=C(OC)C=CC=C4OC)=C(COCC)N1 |
| Formula | C24H23ClN4O6 |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |