Reagents and instruments for immunology, cell biology and molecular biology.
 
> BMS-986251 is an orally active and selective RORγt inverse agonist with an EC50 of 12 nM for RORγt GAL4. BMS-986251 inhibits IL-17 with an EC50 of 24 nM in human whole blood assay. BMS-986251 demonstrates robust efficacy in mouse acanthosis and Imiquimod-induced models (preclinical models of psoriasis). [[2460133-35-9]]

BMS-986251 is an orally active and selective RORγt inverse agonist with an EC50 of 12 nM for RORγt GAL4. BMS-986251 inhibits IL-17 with an EC50 of 24 nM in human whole blood assay. BMS-986251 demonstrates robust efficacy in mouse acanthosis and Imiquimod-induced models (preclinical models of psoriasis). [[2460133-35-9]]

Print Print
Please log in

Cat# orb1910826-100mg

Size : 100mg

Brand : Biorbyt


    BMS-986251

    BMS-986251

    Catalog Number: orb1910826

    Catalog Numberorb1910826
    CategorySmall Molecules
    DescriptionBMS-986251 is an orally active and selective RORγt inverse agonist with an EC50 of 12 nM for RORγt GAL4. BMS-986251 inhibits IL-17 with an EC50 of 24 nM in human whole blood assay. BMS-986251 demonstrates robust efficacy in mouse acanthosis and Imiquimod-induced models (preclinical models of psoriasis).
    CAS Number[2460133-35-9]
    MW667.6072
    SMILES[C@H]1([C@H](C(=O)N2[C@@]3(CCC4=CC(C(C(F)(F)F)(F)C(F)(F)F)=CC=C4[C@]3(S(=O)(=O)C3C=CC(F)=CC=3)CC2)03)CC[C@@H](C(=O)O03)C1)C
    FormulaC30NO5F8SH29
    NoteFor research use only
    Expiration Date12 months from date of receipt.