Our BCL6 break apart probe is designed to detect BCL6 translocations. The probe comes labeled in green and orange, but can be customized to meet your needs.
Gene Background: B-Cell Lymphoma 6 (BCL6) encodes a zinc finger-type transcription factor that binds target DNA sequences to inhibit transcription by recruiting other repressor proteins to the binding site. BCL6 translocations are present in various lymphoma subsets, especially diffuse large B-cell lymphoma, where it’s the most frequent genetic abnormality, occurring in roughly 40% of cases. Rearrangements are also present in follicular lymphoma (5-10% of cases), Hodgkin lymphoma, and B-cell leukemia. The most common result of these rearrangements are fusion with IGH genes, accounting for about half of all known BCL6 translocations. However, the gene has also been shown to form fusions with an additional 30 partner genes.
Source: NIH.gov
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
Gene Summary
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Gene Details
Gene Symbol: BCL6
Gene Name: B-cell CLL/lymphoma 6
Chromosome: CHR3: 187439164-187463513
Locus: 3q27.3