AZD1208 [1204144-28-4]
Cat# HY-15604-5mg
Size : 5mg
Brand : MedChemExpress
AZD1208 is an orally bioavailable, highly selective PIM kinases inhibitor.
For research use only. We do not sell to patients.
AZD1208 Chemical Structure
CAS No. : 1204144-28-4
This product is a controlled substance and not for sale in your territory.
Based on 14 publication(s) in Google Scholar
Other Forms of AZD1208:
- AZD1208 hydrochloride Get quote
View All Pim Isoform Specific Products:
Description |
AZD1208 is an orally bioavailable, highly selective PIM kinases inhibitor[1]. |
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IC50 & Target |
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In Vitro |
AZD1208 shows good antiproliferative activity in a megakaryoblastic leukemia cell line, MOLM-16, with GI50 values less than 100 nM[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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Molecular Weight |
379.48 |
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Formula |
C21H21N3O2S |
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CAS No. |
1204144-28-4 |
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Appearance |
Solid |
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Color |
Light yellow to yellow |
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SMILES |
O=C(NC/1=O)SC1=C/C2=C(N3C[C@H](N)CCC3)C(C4=CC=CC=C4)=CC=C2 |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 50 mg/mL (131.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.71% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.6352 mL | 13.1759 mL | 26.3518 mL | 65.8796 mL |
5 mM | 0.5270 mL | 2.6352 mL | 5.2704 mL | 13.1759 mL | |
10 mM | 0.2635 mL | 1.3176 mL | 2.6352 mL | 6.5880 mL | |
15 mM | 0.1757 mL | 0.8784 mL | 1.7568 mL | 4.3920 mL | |
20 mM | 0.1318 mL | 0.6588 mL | 1.3176 mL | 3.2940 mL | |
25 mM | 0.1054 mL | 0.5270 mL | 1.0541 mL | 2.6352 mL | |
30 mM | 0.0878 mL | 0.4392 mL | 0.8784 mL | 2.1960 mL | |
40 mM | 0.0659 mL | 0.3294 mL | 0.6588 mL | 1.6470 mL | |
50 mM | 0.0527 mL | 0.2635 mL | 0.5270 mL | 1.3176 mL | |
60 mM | 0.0439 mL | 0.2196 mL | 0.4392 mL | 1.0980 mL | |
80 mM | 0.0329 mL | 0.1647 mL | 0.3294 mL | 0.8235 mL | |
100 mM | 0.0264 mL | 0.1318 mL | 0.2635 mL | 0.6588 mL |
AZD1208 Related Classifications
- JAK/STAT Signaling Autophagy Apoptosis
- Pim Autophagy Apoptosis