Reagents and instruments for immunology, cell biology and molecular biology.
 
> AP20187 [195514-80-8]

AP20187 [195514-80-8]

Print Print
Please log in

Cat# T14299-5mg

Size : 5mg

Brand : TargetMol


AP20187

AP20187
AP20187 (B/B Homodimerizer) is a cell-permeable compound used to dimerize FK506-binding protein (FKBP) fusion proteins, thereby initiating biological signaling cascades, gene expression, or disrupting protein-protein interactions.
Catalog No. T14299Cas No. 195514-80-8
Purity:99.80%
Contact us for more batch information
Resource Download
COA LCMS HNMR

AP20187

Catalog No. T14299Cas No. 195514-80-8
AP20187 (B/B Homodimerizer) is a cell-permeable compound used to dimerize FK506-binding protein (FKBP) fusion proteins, thereby initiating biological signaling cascades, gene expression, or disrupting protein-protein interactions.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack Size
1 mgIn Stock
5 mgIn Stock
10 mgIn Stock
25 mgIn Stock
50 mgIn Stock
100 mgIn Stock
1 mL x 10 mM (in DMSO)In Stock

Product Introduction

Bioactivity
Description
AP20187 (B/B Homodimerizer) is a cell-permeable compound used to dimerize FK506-binding protein (FKBP) fusion proteins, thereby initiating biological signaling cascades, gene expression, or disrupting protein-protein interactions.
In vitro
Treatment of LNCaP cells with AP20187 (B/B Homodimerizer) at a concentration of 100 nM significantly reduces ro-iCaspase-9 levels, while the smaller, processed, active form of caspase-9 becomes evident.
In vivo
Treatment with AP20187 significantly mitigates the effects of experimental autoimmune encephalomyelitis (EAE) on myelin sheaths in mice, markedly decreasing the prevalence of deteriorating axons and enhancing axonal density within demyelination sites in the lumbar spinal cord of PLP/Fv2E-PERK mice. Additionally, real-time PCR analysis reveals that AP20187 (B/B Homodimerizer) administration at doses of 0.5 mg/kg, 2 mg/kg, or 5 mg/kg notably elevates CHOP mRNA levels in the central nervous system (CNS) of PLP/Fv2E-PERK mice at post-infection day (PID) 12.
AliasB/B Homodimerizer
Chemical Properties
Molecular Weight1482.75
FormulaC82H107N5O20
Cas No.195514-80-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (37.09 mM)
Ethanol: 130 mg/mL (87.67 mM), Sonication is recommended.
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM0.6744 mL3.3721 mL6.7442 mL33.7211 mL
5 mM0.1349 mL0.6744 mL1.3488 mL6.7442 mL
10 mM0.0674 mL0.3372 mL0.6744 mL3.3721 mL
20 mM0.0337 mL0.1686 mL0.3372 mL1.6861 mL
Ethanol
1mg5mg10mg50mg
50 mM0.0135 mL0.0674 mL0.1349 mL0.6744 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

AP 20187AP20187inhibitAP-20187FKBPFK506-binding proteinInhibitor
Related Tags: buy AP20187 | purchase AP20187 | AP20187 cost | order AP20187 | AP20187 chemical structure | AP20187 in vivo | AP20187 in vitro | AP20187 formula | AP20187 molecular weight

You might also be interested by the following products:



Cat#
Description
Cond.
Price Bef. VAT
T2101-50mg
Navitoclax [923564-51-6]
 50mg