General Info
Host: | Rabbit |
Applications: | ELISA/IHC/IP/WB |
Reactivity: | Human/Monkey |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-LILRB3 (580-631) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Biotin |
Isotype: | IgG |
Purification: | Affinity Purified |
Concentration: | 0.74 µg/µl |
Dilution Range: | WB: 1:500DB: 1:20, 000ELISA: 1:20, 000IP: 1:200IHC: 1:50-1:150 |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
Gene Symbol: | LILRB3 |
Gene ID: | 102725035/107987462 |
Uniprot ID: | LIRB3_HUMAN |
Immunogen Region: | 580-631 |
Specificity: | This antibody will detect all three isoforms of human LILRB3 protein. |
Immunogen: | Synthetic peptide taken within amino acid region 580-631 on human LILRB3 protein. |
Description
Tissue Specificity | Detected in monocytes and B-cells. |
Post Translational Modifications | Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2. |
Function | May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). |
Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3Lir-3Leukocyte Immunoglobulin-Like Receptor 3Cd85 Antigen-Like Family Member AImmunoglobulin-Like Transcript 5Ilt-5Monocyte Inhibitory Receptor Hl9Cd Antigen Cd85a |
Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 antibodyAnti-Lir-3 antibodyAnti-Leukocyte Immunoglobulin-Like Receptor 3 antibodyAnti-Cd85 Antigen-Like Family Member A antibodyAnti-Immunoglobulin-Like Transcript 5 antibodyAnti-Ilt-5 antibodyAnti-Monocyte Inhibitory Receptor Hl9 antibodyAnti-Cd Antigen Cd85a antibodyAnti-LILRB3 antibodyAnti-ILT5 antibodyAnti-LIR3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance